About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glra2tm1.2Lngu
targeted mutation 1.2, Laurent Nguyen
MGI:5550561
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Glra2tm1.2Lngu/Y
Tg(mI56i-cre,EGFP)1Kc/0 		involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1 MGI:5550563
cx2
 		Glra2tm1.2Lngu/Glra2tm1.2Lngu
Tg(mI56i-cre,EGFP)1Kc/0 		involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1 MGI:5550564


Genotype
MGI:5550563
cx1
Allelic
Composition		 Glra2tm1.2Lngu/Y
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra2tm1.2Lngu mutation (0 available); any Glra2 mutation (9 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal migration ( J:202763 )
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream
abnormal embryonic/fetal subventricular zone morphology ( J:202763 )
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream

cellular
abnormal neuronal migration ( J:202763 )
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream




Genotype
MGI:5550564
cx2
Allelic
Composition		 Glra2tm1.2Lngu/Glra2tm1.2Lngu
Tg(mI56i-cre,EGFP)1Kc/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * FVB/N * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glra2tm1.2Lngu mutation (0 available); any Glra2 mutation (9 available)
Tg(mI56i-cre,EGFP)1Kc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuronal migration ( J:202763 )
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream
abnormal embryonic/fetal subventricular zone morphology ( J:202763 )
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream

cellular
abnormal neuronal migration ( J:202763 )
• fewer GFP+ cortical interneurons migrating into the cortical wall at E15.5
• however, only neurons traveling in the subventricular zone migratory stream




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory