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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mfap5tm1Mech
targeted mutation 1, Robert P Mecham
MGI:5551608
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mfap5tm1Mech/Mfap5tm1Mech Not Specified MGI:5551609
cx2
 		Mfap2tm1Mech/Mfap2tm1Mech
Mfap5tm1Mech/Mfap5tm1Mech 		involves: 129X1/SvJ MGI:5551611


Genotype
MGI:5551609
hm1
Allelic
Composition		 Mfap5tm1Mech/Mfap5tm1Mech
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfap5tm1Mech mutation (0 available); any Mfap5 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:203960 )
N
• mice exhibit normal monocyte and macrophage counts

cardiovascular system
cardiovascular system phenotype ( J:203960 )
N
• mice exhibit normal blood pressure and heart weight

skeleton
skeleton phenotype ( J:203960 )
N
• mice exhibit normal bone mass and architecture

hematopoietic system




Genotype
MGI:5551611
cx2
Allelic
Composition		 Mfap2tm1Mech/Mfap2tm1Mech
Mfap5tm1Mech/Mfap5tm1Mech
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfap2tm1Mech mutation (0 available); any Mfap2 mutation (14 available)
Mfap5tm1Mech mutation (0 available); any Mfap5 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal compact bone morphology ( J:203960 )
• reduced medullary volume
abnormal compact bone volume ( J:203960 )
• increased bone volume fraction in cortical bone due to reduced marrow cavity

immune system
immune system phenotype ( J:203960 )
N
• mice exhibit normal macrophage counts

cardiovascular system
cardiovascular system phenotype ( J:203960 )
N
• mice exhibit normal blood pressure and heart weight
abnormal aorta morphology ( J:203960 )
• increased outer diameter at physiological pressures at 6 months

hematopoietic system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory