All Phenotypes Rhbdf1<tm1.1Mfm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rhbdf1^tm1.1Mfm
targeted mutation 1.1, Matthew Freeman
MGI:5551620

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm	B6.129S-Rhbdf1^tm1.1Mfm	MGI:5551635
hm2	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac	MGI:5551633
hm3	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J	MGI:5551634
cx4	Rhbdf1^tm1.1Mfm/Rhbdf1⁺ Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac	MGI:5551636
cx5	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac	MGI:5551638
cx6	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J	MGI:5551639
cx7	Rhbdf1^tm1.1Mfm/Rhbdf1⁺ Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J	MGI:5551637

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm
Genetic Background	B6.129S-Rhbdf1^tm1.1Mfm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf1^tm1.1Mfm mutation (0 available); any Rhbdf1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:203951 )

• mice die between P9 and P20

behavior/neurological

ataxia ( J:203951 )

• with hind legs being particularly affected

impaired coordination ( J:203951 )

• uncoordinated with hind legs being particularly affected

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf1^tm1.1Mfm mutation (0 available); any Rhbdf1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:203951 )

• mice survive 25 to 40 days

behavior/neurological

increased eating frequency ( J:203951 )

• obsessive eating around time of weaning

impaired coordination ( J:203951 )

• transient around 14 to 18 days

growth/size/body

decreased body weight ( J:203951 )

weight loss ( J:203951 )

• severe

nervous system

intracerebral hemorrhage ( J:203951 )

cardiovascular system

intracerebral hemorrhage ( J:203951 )

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf1^tm1.1Mfm mutation (0 available); any Rhbdf1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:203951 )

• mice die by P60

postnatal lethality, incomplete penetrance ( J:203951 )

endocrine/exocrine glands

abnormal pancreatic acinus morphology ( J:203951 )

• pale

absent pancreatic acinar cell zymogen granule ( J:203951 )

pancreatic acinar hypoplasia ( J:203951 )

small thymus ( J:203951 )

hematopoietic system

hematopoietic system phenotype ( J:203951 )

N	• erythroid, myeloid and megakaryocyte maturation appear normal

small thymus ( J:203951 )

decreased bone marrow cell number ( J:203951 )

small spleen ( J:203951 )

growth/size/body

decreased body weight ( J:203951 )

• small and malnourished 6 to 14 days after birth

slow postnatal weight gain ( J:203951 )

• mice fail to gain weight after birth

adipose tissue

decreased white adipose tissue amount ( J:203951 )

• absent

cardiovascular system

abnormal heart morphology ( J:203951 )

• evidence of myocardial infarction with thrombi in and around the ventricular septum close to the site of infarction

homeostasis/metabolism

abnormal cardiac thrombosis ( J:203951 )

• thrombi in and around the ventricular septum close to the site of myocardial infarction

digestive/alimentary system

abnormal pancreatic acinus morphology ( J:203951 )

• pale

absent pancreatic acinar cell zymogen granule ( J:203951 )

pancreatic acinar hypoplasia ( J:203951 )

immune system

small thymus ( J:203951 )

small spleen ( J:203951 )

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1⁺ Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhbdf1^tm1.1Mfm mutation (0 available); any Rhbdf1 mutation (43 available)
Rhbdf2^tm1.1Mfm mutation (1 available); any Rhbdf2 mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203951 )

N	• mice are viable

reproductive system

reproductive system phenotype ( J:203951 )

N	• mice are fertile

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:203951 )

• no mice beyond E9.5 to E10.5

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1^tm1.1Mfm Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:203951 )

• no mice beyond E9.5 to E10.5

Allelic Composition	Rhbdf1^tm1.1Mfm/Rhbdf1⁺ Rhbdf2^tm1.1Mfm/Rhbdf2^tm1.1Mfm
Genetic Background	involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203951 )

N	• mice are viable

reproductive system

reproductive system phenotype ( J:203951 )

N	• mice are fertile

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