Phenotypes associated with this allele

• Allele Symbol: Mir205^tm1.2Yir
• Allele Name: targeted mutation 1.2, Rui Yi
• Allele ID: MGI:5551770
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir205^tm1.2Yir/Mir205^tm1.2Yir	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5554291
cx2	Mir205^tm1.2Yir/Mir205^tm1.2Yir Tg(KRT14-RFP)#Efu/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5554292

Genotype
MGI:5554291

hm1

• Allelic Composition: Mir205^tm1.2Yir/Mir205^tm1.2Yir
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:201587 )

• mice usually die by P10

integument

integument phenotype ( J:201587 )

N • mice exhibit normal skin barrier function

abnormal coat/ hair morphology ( J:201587 )

• less well-developed hair coats at P5

abnormal hair follicle morphology ( J:201587 )

• short and mis-angled

abnormal hair follicle development ( J:201587 )

• impaired proliferation of progenitors and stem cells in hair follicles

thin epidermis ( J:201587 )

• at P4.5

abnormal skin physiology ( J:201587 )

• impaired proliferation of progenitors and stem cells in hair follicles

digestive/alimentary system

abnormal digestive system physiology ( J:201587 )

• impaired proliferation of basal cells in stratified epithelium of the esophagus and tongue

behavior/neurological

weakness ( J:201587 )

• at P5

Genotype
MGI:5554292

cx2

• Allelic Composition: Mir205^tm1.2Yir/Mir205^tm1.2Yir; Tg(KRT14-RFP)#Efu/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

integument

abnormal skin physiology ( J:201587 )

• impairs the proliferation of interfollicular progenitors with premature cell-cycle exit