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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wapltm1.1Jmpt
targeted mutation 1.1, Jan-Michael Peters
MGI:5551791
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: 129 * C57BL/6 * C57BL/6NTac * SJL MGI:5551813
cn2
 		Espl1tm1.1Kna/Espl1tm1.2Kna
Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL MGI:5551815


Genotype
MGI:5551813
cn1
Allelic
Composition		 Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (997 available)
Wapltm1.1Jmpt mutation (0 available); any Wapl mutation (169 available)
Wapltm1.2Jmpt mutation (0 available); any Wapl mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle ( J:205429 )
• impaired cell cycle progression in tamoxifen-treated mouse embryonic cells with improper chromosome segregation
abnormal mitosis ( J:205429 )
• tamoxifen-treated mouse embryonic cells exhibit improper chromosome segregation
absent fibroblast proliferation ( J:205429 )
• in tamoxifen-treated mouse embryonic cells stimulated with serum




Genotype
MGI:5551815
cn2
Allelic
Composition		 Espl1tm1.1Kna/Espl1tm1.2Kna
Wapltm1.1Jmpt/Wapltm1.2Jmpt
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6NTac * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Espl1tm1.1Kna mutation (0 available); any Espl1 mutation (95 available)
Espl1tm1.2Kna mutation (0 available); any Espl1 mutation (95 available)
Gt(ROSA)26Sortm9(cre/ESR1)Arte mutation (2 available); any Gt(ROSA)26Sor mutation (997 available)
Wapltm1.1Jmpt mutation (0 available); any Wapl mutation (169 available)
Wapltm1.2Jmpt mutation (0 available); any Wapl mutation (169 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal mitosis ( J:205429 )
• tamoxifen-treated mouse embryonic fibroblasts exhibit diplo-chromosomes with unseparated arms unlike in control cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory