Phenotypes associated with this allele

• Allele Symbol: Fermt3^tm2.1Ref
• Allele Name: targeted mutation 2.1, Reinhard Fassler
• Allele ID: MGI:5551978
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fermt3^tm2.1Ref/Fermt3^tm2.1Ref Tg(Cd4-cre)1Cwi/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2	MGI:5551981

Genotype
MGI:5551981

cn1

• Allelic Composition: Fermt3^tm2.1Ref/Fermt3^tm2.1Ref; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal effector T cell morphology ( J:203436 )

• effector T cells exhibit defective LFA-1 and VLA-4 integrin adhesion under shear flow conditions compared with control cells

• however, rolling on low-density P- or E-selectins is normal

abnormal T cell physiology ( J:203436 )

• effector T cells fail to arrest on inflamed lymph node vessels and fail to enter inflamed skin compared with control cells

• chemokine-stimulated effector T cells exhibit impaired motility inside inflamed lymph nodes compared with control cells

• however, effector T cells are recruited to skin-draining lymph nodes

hematopoietic system

abnormal effector T cell morphology ( J:203436 )

• effector T cells exhibit defective LFA-1 and VLA-4 integrin adhesion under shear flow conditions compared with control cells

• however, rolling on low-density P- or E-selectins is normal

abnormal T cell physiology ( J:203436 )

• effector T cells fail to arrest on inflamed lymph node vessels and fail to enter inflamed skin compared with control cells

• chemokine-stimulated effector T cells exhibit impaired motility inside inflamed lymph nodes compared with control cells

• however, effector T cells are recruited to skin-draining lymph nodes