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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vangl2tm2.1Mdea
targeted mutation 2.1, Michael R Deans
MGI:5551989
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vangl2tm2.1Mdea/Vangl2tm2.1Mdea involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5552005
cn2
 		Tg(Pax2-cre)1Akg/0
Vangl2tm1.2Mdea/Vangl2tm2.1Mdea 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:5552006


Genotype
MGI:5552005
hm1
Allelic
Composition		 Vangl2tm2.1Mdea/Vangl2tm2.1Mdea
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl2tm2.1Mdea mutation (1 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:201321 )
N
• mice are viable




Genotype
MGI:5552006
cn2
Allelic
Composition		 Tg(Pax2-cre)1Akg/0
Vangl2tm1.2Mdea/Vangl2tm2.1Mdea
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pax2-cre)1Akg mutation (2 available)
Vangl2tm1.2Mdea mutation (0 available); any Vangl2 mutation (34 available)
Vangl2tm2.1Mdea mutation (1 available); any Vangl2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:201321 )
N
• cochlear length and number of turns are normal
abnormal Deiters cell morphology ( J:201321 )
• shifted out of the second and third outer hair cell rows and not centrally positioned between the hair cell lateral edges
abnormal pillar cell morphology ( J:201321 )
• at P10 and P12, more pronounced in the apical turn
• more compact and incorrectly positioned compared with control mice
abnormal auditory brainstem response ( J:201321 )
• reduced ABR amplitude
• however, the overall shape of the waveform is normal
abnormal distortion product otoacoustic emission ( J:201321 )
• decreased amplitude of the distortion product

nervous system




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory