integument
• at 3 weeks of age homozygotes have some hair on their legs, tail, and face, but by 8 weeks of age are hairless with only their straight whiskers left
|
• histology at 9 and 11 weeks of age shows very dilated or cystic hair follicles
|
• the skin is thick and wrinkly as early as 1 week of age
|
thick skin
(
J:206787
)
growth/size/body
• smaller body size than unaffected littermates
|
mortality/aging
• with 7 homozygotes out of 132 pups born from heterozygous intercrosses there are significantly fewer than the predicted 25% homozygotes born
|
limbs/digits/tail