Analysis Tools
homeostasis/metabolism
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• CCX140-B treatment improves insulin sensitivity, reduced fasting glucose levels and reduced fasting insulin levels observed in mice fed a high fat diet
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• CCX140-B treatment improves albuminuria observed in mice fed a high fat diet
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• CCX140-B treatment inhibits expression of the human sequence and CCL2-mediated calcium mobilization; improves albuminuria, insulin sensitivity, glomerular hypertrophy and podocyte density diminution; reduced fasting glucose levels, fasting insulin levels and inflammatory macrophages in epididymal fat pads observed in mice fed a high fat diet
• however, CCX140-B treatment does not alter weight gain observed in mice fed a high fat diet
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renal/urinary system
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• CCX140-B treatment improves albuminuria observed in mice fed a high fat diet
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• CCX140-B treatment glomerular hypertrophy and podocyte density diminution observed in mice fed a high fat diet
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• CCX140-B treatment glomerular hypertrophy and podocyte density diminution observed in mice fed a high fat diet
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immune system
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• mice exhibit normal numbers of peripheral blood monocytes and leukocyte chemotaxis
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• CCX140-B treatment improves inflammatory macrophages in epididymal fat pads observed in mice fed a high fat diet
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hematopoietic system
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• CCX140-B treatment improves inflammatory macrophages in epididymal fat pads observed in mice fed a high fat diet
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