Phenotypes associated with this allele

• Allele Symbol: Trms
• Allele Name: tremulous
• Allele ID: MGI:5552892
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Trms/Trms^+	B6.Cg-Trms/GrsrJ	MGI:5552982
ht2	Trms/Trms^+	STOCK Trms/GrsrJ	MGI:7561898

Genotype
MGI:5552982

ht1

• Allelic Composition: Trms/Trms⁺
• Genetic Background: B6.Cg-Trms/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

cachexia ( J:206791 )

• Background Sensitivity: on the C57BL/6J background heterozygotes begin to become thinner than littermate controls as early as 4 weeks of age, the ataxia and cachexia progress rapidly and all are dead with severe wasting by 8 weeks of age

mortality/aging

premature death ( J:206791 )

• Background Sensitivity: on the C57BL/6J background all heterozygotes die by 8 weeks of age

behavior/neurological

tremors ( J:206791 )

abnormal locomotor coordination ( J:206791 )

• heterozygotes develop a whole body tremor that is visible when still, and a wobbly, increasingly labored gait, and the posture becomes lower to the ground with movement that seems cautious

ataxia ( J:206791 )

abnormal gait ( J:206791 )

vision/eye

vision/eye phenotype ( J:206791 )

N • ophthalmoscopic examination of 2 heterozgyotes at 7 weeks of age found not abnormalities and electroretinography on 3 heterozygotes at 7 weeks of age and 2 heterozygotes at 6 weeks of age found no abnormalities

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:206791 )

N • ABR testing of one heterozygote at 39 days of age and one heterozygote at 7 weeks of age showed normal hearing

Genotype
MGI:7561898

ht2

• Allelic Composition: Trms/Trms⁺
• Genetic Background: STOCK Trms/GrsrJ

behavior/neurological

tremors ( J:206791 )

abnormal locomotor coordination ( J:206791 )

• heterozygotes develop a whole body tremor that is visible when still, and a wobbly, increasingly labored gait, and the posture becomes lower to the ground with movement that seems cautious

ataxia ( J:206791 )

abnormal gait ( J:206791 )

growth/size/body

cachexia ( J:206791 )

• Background Sensitivity: The phenotype is less severe with a later onset on this mixed genetic background than on the C57BL/6J congenic background

mortality/aging

premature death ( J:206791 )

• Background Sensitivity: on this mixed genetic background that includes CAST/EiJ, FVB/NJ, CBA/J and C57BL/6J the phenotype is less severe than on the C57BL/6J congenic background, with heterozygotes having phenotypic onset anytime between 4 and 8 weeks of age and most living longer than 12 weeks of age and one having lived past 5 months of age