All Phenotypes Klf15<tm2Jain> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Apoe^tm1Unc/Apoe^tm1Unc Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0	involves: 129P2/OlaHsd * FVB/N	MGI:5552967
cn2	Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0	involves: FVB/N	MGI:5552966

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0 Apoe^tm1Unc/Apoe^tm1Unc aortas develop more atherosclerotic lesions after a high fat diet challenge

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:203920 )

N	• mice fed a high fat diet exhibit the same circulating levels of cholesterol and triglycerides as in Apoe^tm1Unc homozygotes

immune system

blood vessel inflammation ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

increased macrophage cell number ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

cardiovascular system

increased susceptibility to atherosclerosis ( J:203920 )

• in mice fed a high fat diet compared with Apoe^tm1Unc homozygotes

vascular smooth muscle hypoplasia ( J:203920 )

• decreased vascular smooth muscle cells in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

blood vessel inflammation ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

muscle

vascular smooth muscle hypoplasia ( J:203920 )

• decreased vascular smooth muscle cells in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

hematopoietic system

increased macrophage cell number ( J:203920 )

• increased macrophage in the aortic wall and atherosclerotic lesions of mice fed a high fat diet with Apoe^tm1Unc homozygotes

Allelic Composition	Klf15^tm2Jain/Klf15^tm2Jain Tg(Tagln-cre)1Jjl/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf15^tm2Jain mutation (0 available); any Klf15 mutation (19 available)
Tg(Tagln-cre)1Jjl mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:203920 )

N	• mice are viable and born in expected Mendelian ratios

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24