Phenotypes associated with this allele

• Allele Symbol: Ccdc7a^{Tg(Prnp-Sirt1)10Imai}
• Allele Name: transgene insertion 10, Shin-ichiro Imai
• Allele ID: MGI:5553098
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Ccdc7a^Tg(Prnp-Sirt1)10Imai/?	B6.Cg-Ccdc7a^Tg(Prnp-Sirt1)10Imai	MGI:5553105

Genotype
MGI:5553105

ot1

• Allelic Composition: Ccdc7a^{Tg(Prnp-Sirt1)10Imai}/?
• Genetic Background: B6.Cg-Ccdc7a^{Tg(Prnp-Sirt1)10Imai}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased food intake ( J:203814 )

• 20 month old mice show an increase in nocturnal food intake

hyperactivity ( J:162852 , J:203814 )

• mice show higher physical activity during the dark time at 20 months of age, but not at 4 months of age, compared to controls (J:203814)

♀ • in fasted female, but not male, mice (J:162852)

increased vertical activity ( J:162852 )

♂ • in diet-restricted male mice, particularly in the dark phase

hyperactivity elicited by feed restriction ( J:162852 )

• increased food-anticipating activity in diet-restricted mice

abnormal non-rapid eye movement sleep pattern ( J:203814 )

• aged mice show higher delta power in non-REM sleep, suggesting better or deeper sleep than aged controls

homeostasis/metabolism

increased body temperature ( J:162852 , J:203814 )

• in fasted or diet-restricted mice (J:162852)

• rectal body temperature after ghrelin injection (J:162852)

• 20 month old mice show an increase in rectal body temperature (J:203814)

increased energy expenditure ( J:203814 )

• 20 month old mice show a trend of increased energy expenditure during the dark time

increased oxygen consumption ( J:203814 )

• 20 month old mice show an increase in oxygen consumption

adipose tissue

abnormal brown adipose tissue physiology ( J:203814 )

• marker analysis indicates that brown adipose tissue activity is higher during the light time and lower during the dark time

mortality/aging

extended life span ( J:203814 )

• females and males show an approximate 16% and 9%, respectively, extension in median life span

• mice show a delay in age-associated mortality, however the slopes of age-associated mortality change defining the rate of ageing are normal

• mice show a delay in cancer-dependent death incidence, however the slopes of accumulating death incidents and the spectrum of cancers does not differ from controls

slow aging ( J:203814 )

• onset of age-associated physiological decline is delayed without affecting the rate of aging

• unlike in controls which show disturbed sarcomeres and abnormal mitochondria in skeletal muscle at 20 months of age, mutants show well organized sarcomeres and fewer abnormal mitochondria, as well as increased numbers of and smaller size of mitochondria

nervous system

abnormal neuron physiology ( J:203814 )

• expression analysis suggests that neural activity in the dorsomedial and lateral hypothalamic nuclei is enhanced during the dark time of aged mutants