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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tbx18tm1.1Mwmy
targeted mutation 1.1, Mark W Majesky
MGI:5553116
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tbx18tm1.1Mwmy/Tbx18tm1.1Mwmy involves: 129 * C57BL/6J MGI:5553117
cx2
Taglntm1Liw/Tagln+
Tbx18tm1.1Mwmy/Tbx18tm1.1Mwmy
involves: 129 * C57BL/6J MGI:5553118


Genotype
MGI:5553117
hm1
Allelic
Composition
Tbx18tm1.1Mwmy/Tbx18tm1.1Mwmy
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx18tm1.1Mwmy mutation (0 available); any Tbx18 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 24 hours of birth

cardiovascular system
• contains scattered clusters of densely packed nucleated erythroid cells covered by a continuous layer of epicardial layer without pericardial hemorrhage
• reduced surface area coverage of the subepicardial coronary vascular plexus at E12.5
• disorganized coronary vascular plexus at E14.5
• however, arterial-venous specification of coronary endothelial cells is normal
• fewer large diameter coronary vessels in the subepicardium and ventricular septum at E18.5
• irregular covering of the heart at E12.5
• occasional cyst-like protrusions at E12.5

growth/size/body
• small chest cavity

renal/urinary system

respiratory system

skeleton
• fusion bands of the proximal ribs
• misshapen distal ribs with evidence of distal rib fusions
• fusion bands of the proximal ribs
• misshapen distal ribs with evidence of distal rib fusions
• absent or reduced
• absent or reduced

muscle
• contains scattered clusters of densely packed nucleated erythroid cells covered by a continuous layer of epicardial layer without pericardial hemorrhage




Genotype
MGI:5553118
cx2
Allelic
Composition
Taglntm1Liw/Tagln+
Tbx18tm1.1Mwmy/Tbx18tm1.1Mwmy
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taglntm1Liw mutation (1 available); any Tagln mutation (28 available)
Tbx18tm1.1Mwmy mutation (0 available); any Tbx18 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• reduced smooth muscle content and shorter overall smooth muscle coverage at birth
• less developed branching network of subepicardial conduit vessels
• reduced smooth muscle content and shorter overall smooth muscle coverage at birth
• reduced overall diameter of the coronary stems and reduced branching index

muscle
• reduced smooth muscle content and shorter overall smooth muscle coverage at birth





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory