About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tbx18tm1.1Mwmy
targeted mutation 1.1, Mark W Majesky
MGI:5553116
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tbx18tm1.1Mwmy/Tbx18tm1.1Mwmy involves: 129 * C57BL/6J MGI:5553117
cx2
Taglntm1Liw/Tagln+
Tbx18tm1.1Mwmy/Tbx18tm1.1Mwmy
involves: 129 * C57BL/6J MGI:5553118


Genotype
MGI:5553117
hm1
Allelic
Composition
Tbx18tm1.1Mwmy/Tbx18tm1.1Mwmy
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tbx18tm1.1Mwmy mutation (0 available); any Tbx18 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within 24 hours of birth

cardiovascular system
• contains scattered clusters of densely packed nucleated erythroid cells covered by a continuous layer of epicardial layer without pericardial hemorrhage
• reduced surface area coverage of the subepicardial coronary vascular plexus at E12.5
• disorganized coronary vascular plexus at E14.5
• however, arterial-venous specification of coronary endothelial cells is normal
• fewer large diameter coronary vessels in the subepicardium and ventricular septum at E18.5
• irregular covering of the heart at E12.5
• occasional cyst-like protrusions at E12.5

growth/size/body
• small chest cavity

renal/urinary system

respiratory system

skeleton
• fusion bands of the proximal ribs
• misshapen distal ribs with evidence of distal rib fusions
• fusion bands of the proximal ribs
• misshapen distal ribs with evidence of distal rib fusions
• absent or reduced
• absent or reduced

muscle
• contains scattered clusters of densely packed nucleated erythroid cells covered by a continuous layer of epicardial layer without pericardial hemorrhage




Genotype
MGI:5553118
cx2
Allelic
Composition
Taglntm1Liw/Tagln+
Tbx18tm1.1Mwmy/Tbx18tm1.1Mwmy
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taglntm1Liw mutation (1 available); any Tagln mutation (28 available)
Tbx18tm1.1Mwmy mutation (0 available); any Tbx18 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• reduced smooth muscle content and shorter overall smooth muscle coverage at birth
• less developed branching network of subepicardial conduit vessels
• reduced smooth muscle content and shorter overall smooth muscle coverage at birth
• reduced overall diameter of the coronary stems and reduced branching index

muscle
• reduced smooth muscle content and shorter overall smooth muscle coverage at birth





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
12/10/2024
MGI 6.24
The Jackson Laboratory