All Phenotypes Igh<tm1.1Vmd> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh^tm1.1Vmd
targeted mutation 1.1, Vishva M Dixit
MGI:5553164

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igh^tm1.1Vmd/Igh^tm1.1Vmd	involves: C57BL/6	MGI:5553165
ht2	Igh^tm1.1Vmd/Igh⁺	involves: C57BL/6	MGI:5553166

Allelic Composition	Igh^tm1.1Vmd/Igh^tm1.1Vmd
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.1Vmd mutation (0 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:201147 )

N	• splenocyte cultures stimulated with LPS alone or LPS and IL4 produce normal numbers of IgM+ cells • mice exhibit normal somatic hypermutation

abnormal class switch recombination ( J:201147 )

• 10-fold reduction in class switch recombination in IgG1+ clones and 7-fold increase in IgE+ clones after LPS and IL4 stimulation

• class switch recombination is largely direct instead of sequential

• endogenous Switch mu intraswitch recombination is reduced compared to in wild-type mice

increased IgE level ( J:201147 )

• 6-fold increase in IgE+ B cells in splenocyte cultures stimulated with LPS and IL4

• 4-fold increase in IgE+ cells in splenocyte cultures stimulated with LPS alone

• in unchallenged mice

• in mice in response to a variety of systemic and local challenges (TNP-OVA and infection with Nippostrongylus brasiliensis)

decreased IgG1 level ( J:201147 )

• 11-fold decrease in IgG1+ B cells in splenocyte cultures stimulated with LPS and IL4

decreased IgG3 level ( J:201147 )

• from splenocytes stimulated with LPS alone

hematopoietic system

abnormal class switch recombination ( J:201147 )

• 10-fold reduction in class switch recombination in IgG1+ clones and 7-fold increase in IgE+ clones after LPS and IL4 stimulation

• class switch recombination is largely direct instead of sequential

• endogenous Switch mu intraswitch recombination is reduced compared to in wild-type mice

increased IgE level ( J:201147 )

• 6-fold increase in IgE+ B cells in splenocyte cultures stimulated with LPS and IL4

• 4-fold increase in IgE+ cells in splenocyte cultures stimulated with LPS alone

• in unchallenged mice

• in mice in response to a variety of systemic and local challenges (TNP-OVA and infection with Nippostrongylus brasiliensis)

decreased IgG1 level ( J:201147 )

• 11-fold decrease in IgG1+ B cells in splenocyte cultures stimulated with LPS and IL4

decreased IgG3 level ( J:201147 )

• from splenocytes stimulated with LPS alone

Allelic Composition	Igh^tm1.1Vmd/Igh⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1.1Vmd mutation (0 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:201147 )

• 3-fold reduction in class switch recombination in IgG1+ clones and 5-fold increase in IgE+ clones after LPS and IL4 stimulation

hematopoietic system

abnormal class switch recombination ( J:201147 )

• 3-fold reduction in class switch recombination in IgG1+ clones and 5-fold increase in IgE+ clones after LPS and IL4 stimulation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24