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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nle1tm1.1Cota
targeted mutation 1.1, Michel Cohen-Tannoudji
MGI:5553357
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Nle1tm1Cba/Nle1tm1.1Cota
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:5553371
cn2
 		Nle1tm1Cba/Nle1tm1.1Cota
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:5553372
cn3
 		Nle1tm1Cba/Nle1tm1.1Cota
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:5553374


Genotype
MGI:5553371
cn1
Allelic
Composition		 Nle1tm1Cba/Nle1tm1.1Cota
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Nle1tm1.1Cota mutation (0 available); any Nle1 mutation (27 available)
Nle1tm1Cba mutation (0 available); any Nle1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Severe hypocellularity in Nle1tm1Cba/Nle1tm1.1Cota Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ bone marrow, with capillaries saturated with erythrocytes

mortality/aging
premature death ( J:204063 )
• mice die 10 to 13 days after tamoxifen treatment

immune system
decreased granulocyte number ( J:204063 )
• in tamoxifen-treated mice
decreased NK cell number ( J:204063 )
• in tamoxifen-treated mice
decreased T cell number ( J:204063 )
• in tamoxifen-treated mice
decreased macrophage cell number ( J:204063 )
• in tamoxifen-treated mice
abnormal immune system organ morphology ( J:204063 )
• defects in secondary lymphoid organs in tamoxifen-treated mice
thymus hypoplasia ( J:204063 )
• in tamoxifen-treated mice
spleen hypoplasia ( J:204063 )
• in tamoxifen-treated mice

digestive/alimentary system
abnormal intestinal epithelium morphology ( J:204063 )
• 7 to 9 days after tamoxifen treatment

cellular
abnormal ribosome biogenesis ( J:204063 )
• tamoxifen-treated mice exhibit impaired biogenesis of large ribosomal subunit in hematopoietic stem cell and multipotent progenitor compared with control mice

hematopoietic system
hematopoietic system phenotype ( J:204063 )
N
• hematopoietic stem cell mobilization occurs normally in tamoxifen-treated mice
thymus hypoplasia ( J:204063 )
• in tamoxifen-treated mice
impaired hematopoiesis ( J:204063 )
• tamoxifen-treated mice exhibit cell autonomous defects in hematopoiesis
abnormal bone marrow cell morphology/development ( J:204063 )
• in tamoxifen-treated mice
• tamoxifen-treated mice exhibit impaired biogenesis of large ribosomal subunit in hematopoietic stem cell and multipotent progenitor compared with control mice
decreased bone marrow cell number ( J:204063 )
• severe in tamoxifen-treated mice
abnormal common lymphocyte progenitor cell morphology ( J:204063 )
• decreased in tamoxifen-treated mice
decreased granulocyte number ( J:204063 )
• in tamoxifen-treated mice
decreased NK cell number ( J:204063 )
• in tamoxifen-treated mice
decreased T cell number ( J:204063 )
• in tamoxifen-treated mice
decreased macrophage cell number ( J:204063 )
• in tamoxifen-treated mice
spleen hypoplasia ( J:204063 )
• in tamoxifen-treated mice
abnormal hematopoietic stem cell physiology ( J:204063 )
• reduced hematopoietic stem cell and multipotent progenitor quiescence in tamoxifen-treated mice

endocrine/exocrine glands
thymus hypoplasia ( J:204063 )
• in tamoxifen-treated mice




Genotype
MGI:5553372
cn2
Allelic
Composition		 Nle1tm1Cba/Nle1tm1.1Cota
Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(cre/ERT2)Brn mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Nle1tm1.1Cota mutation (0 available); any Nle1 mutation (27 available)
Nle1tm1Cba mutation (0 available); any Nle1 mutation (27 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:204063 )
N
• tamoxifen-treated mice exhibit rescued total bone marrow and LSK cells




Genotype
MGI:5553374
cn3
Allelic
Composition		 Nle1tm1Cba/Nle1tm1.1Cota
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Nle1tm1.1Cota mutation (0 available); any Nle1 mutation (27 available)
Nle1tm1Cba mutation (0 available); any Nle1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:204063 )
N
• mice exhibit normal numbers of bone marrow pre-B cells, immature B cells and splenic mature B cells
• mice exhibit normal survival, proliferation and maturation of restricted progenitors

immune system
immune system phenotype ( J:204063 )
N
• mice exhibit normal numbers of bone marrow pre-B cells, immature B cells and splenic mature B cells
• mice exhibit normal survival, proliferation and maturation of restricted progenitors




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory