Analysis Tools
behavior/neurological
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• mice exhibit a normal response to agonist U50,488-induced analgesia relative to control mice, as shown by similarly increased tail withdrawal latencies in the warm water tail-flick assay
• baseline tail withdrawal latencies are not significantly altered in the tail-flick assay
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• mice exhibit significantly greater locomotor sensitization to cocaine (15 mg/kg) than control mice at day 8 of testing
• however, no differences are detected in a cocaine conditioned place preference paradigm following conditioning with 5 mg/kg or 1.25 mg/kg cocaine
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• mice spend significantly more time than control mice in the center of the open field during the final 45 min of the test session, indicating an anxiolytic-like effect
• mice show significantly shorter latencies to first enter the light side of the light/dark box, with no differences in total time spent in the light compartment relative to control mice
• however, no differences are detected in open arm time or open arm entries in the elevated plus maze test
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