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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ddx4tm1.1(cre)Dcp
targeted mutation 1.1, David C Page
MGI:5554579
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ddx4tm1.1(cre)Dcp/Ddx4+
Rb1tm3Tyj/Rb1tm3Tyj
involves: 129S4/SvJae * C57BL/6 MGI:5554595


Genotype
MGI:5554595
cn1
Allelic
Composition
Ddx4tm1.1(cre)Dcp/Ddx4+
Rb1tm3Tyj/Rb1tm3Tyj
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx4tm1.1(cre)Dcp mutation (0 available); any Ddx4 mutation (59 available)
Rb1tm3Tyj mutation (10 available); any Rb1 mutation (111 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• testes of mature males are small relative to controls
• testis weight increases similar to controls in initial 3-4 weeks of age, then begins to decline and remains low in adult males
• when males are housed with wild-type females for 21 weeks from 4 weeks of age, each animal only sires one litter (litter is slightly decreased in size versus wild-type males); control males sire 4-6 litters over 21 week period
• by 2 months of age, males are sterile

endocrine/exocrine glands
• testes of mature males are small relative to controls
• testis weight increases similar to controls in initial 3-4 weeks of age, then begins to decline and remains low in adult males





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory