Phenotypes associated with this allele

• Allele Symbol: Taok2^tm1.2Dkap
• Allele Name: targeted mutation 1.2, David Kapfhamer
• Allele ID: MGI:5554942
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Taok2^tm1.2Dkap/Taok2^tm1.2Dkap	B6(Cg)-Taok2^tm1.2Dkap	MGI:5554944

Genotype
MGI:5554944

hm1

• Allelic Composition: Taok2^tm1.2Dkap/Taok2^tm1.2Dkap
• Genetic Background: B6(Cg)-Taok2^tm1.2Dkap

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to alcohol ( J:206781 )

• mice are acutely resistant to the ataxic effects of ethanol with reduced ataxia recovery time after first and second ethanol injection compared with wild-type mice

• however, mice exhibit normal ethanol-induced hyperactivity

impaired conditioned place preference behavior ( J:206781 )

• towards alcohol

abnormal habituation ( J:206781 )

• impaired in an open field

increased fluid intake ( J:206781 )

• during the beginning of the drinking in the dark study

• however, water consumption is normal later in the study

increased alcohol consumption ( J:206781 )

• during the drinking in the dark study

homeostasis/metabolism

abnormal blood homeostasis ( J:206781 )

• after first alcohol injection, mice exhibit reduced blood ethanol content compared with wild-type mice

• however, blood ethanol content after second ethanol injection is normal