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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Col1a1tm1(tetO-Fos)Wag
targeted mutation 1, Erwin F Wagner
MGI:5555845
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Col1a1tm1(tetO-Fos)Wag/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(Alb1-cre)7Gsc/0 		involves: 129 * C57BL/6 * FVB/N MGI:5586562
cx2
 		Col1a1tm1(tetO-Fos)Wag/Col1a1+
Rag1tm1Mom/Rag1tm1Mom
Tg(KRT5-rtTA)T2D6Sgkd/0 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5555860
cx3
 		Col1a1tm1(tetO-Fos)Wag/Col1a1+
Tg(KRT5-rtTA)T2D6Sgkd/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5555858


Genotype
MGI:5586562
cn1
Allelic
Composition		 Col1a1tm1(tetO-Fos)Wag/Col1a1+
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+
Tg(Alb1-cre)7Gsc/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Fos)Wag mutation (0 available); any Col1a1 mutation (163 available)
Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy mutation (5 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Alb1-cre)7Gsc mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:210545 )
• doxycycline-treated mice develop lethal liver dysplasia

liver/biliary system
abnormal liver morphology ( J:210545 )
• doxycycline-treated mice develop lethal liver dysplasia




Genotype
MGI:5555860
cx2
Allelic
Composition		 Col1a1tm1(tetO-Fos)Wag/Col1a1+
Rag1tm1Mom/Rag1tm1Mom
Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Fos)Wag mutation (0 available); any Col1a1 mutation (163 available)
Rag1tm1Mom mutation (49 available); any Rag1 mutation (123 available)
Tg(KRT5-rtTA)T2D6Sgkd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:201145 )
N
• doxycycline-treated mice exhibit normal keratinocyte proliferation and activation
skin lesions ( J:201145 )
• in doxycycline-treated mice but smaller than in mice with wild-type Rag1
skin hyperplasia ( J:201145 )
• in doxycycline-treated mice but less so than in mice with wild-type Rag1




Genotype
MGI:5555858
cx3
Allelic
Composition		 Col1a1tm1(tetO-Fos)Wag/Col1a1+
Tg(KRT5-rtTA)T2D6Sgkd/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-Fos)Wag mutation (0 available); any Col1a1 mutation (163 available)
Tg(KRT5-rtTA)T2D6Sgkd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:201145 )
• after doxycycline treatment

integument
increased keratinocyte proliferation ( J:201145 )
• with increased survival in doxycycline-treated mice
skin inflammation ( J:201145 )
• in doxycycline-treated mice
alopecia ( J:201145 )
• after doxycycline treatment
absent hair follicles ( J:201145 )
• in doxycycline-treated mice
hyperkeratosis ( J:201145 )
• cornified epidermis in affected skin of doxycycline-treated mice
parakeratosis ( J:201145 )
• in doxycycline-treated mice
epidermal hyperplasia ( J:201145 )
• in doxycycline-treated mice
• however, MMP inhibitor impairs hyperplasia
skin lesions ( J:201145 )
• dry and scaly lesions on the affected skin of doxycycline-treated mice
skin hyperplasia ( J:201145 )
• in doxycycline-treated mice
thick skin ( J:201145 )
• affected skin of doxycycline-treated mice

immune system
immune system phenotype ( J:201145 )
N
• doxycycline-treated mice exhibit normal spleen weight
increased granulocyte number ( J:201145 )
• in the skin of doxycycline-treated mice
increased CD4-positive, alpha-beta T cell number ( J:201145 )
• in the skin of doxycycline-treated mice
• however, doxycycline withdrawal restores CD4+ T cell numbers
skin inflammation ( J:201145 )
• in doxycycline-treated mice

neoplasm
increased incidence of tumors by chemical induction ( J:201145 )
• doxycycline-treated mice exposed to DMBA/TPA develop papillomas at 8 weeks that become ulcerative at 11 weeks
• however, sulindac treatment reduces the number and size of tumors
increased papilloma incidence ( J:201145 )
• doxycycline-treated mice exposed to DMBA/TPA develop papillomas at 8 weeks that become ulcerative at 11 weeks

growth/size/body
decreased body size ( J:201145 )
• after doxycycline treatment

digestive/alimentary system
abnormal forestomach morphology ( J:201145 )
• mild phenotype in doxycycline-treated mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:201145 )
• doxycycline-treated mice exposed to DMBA/TPA develop papillomas at 8 weeks that become ulcerative at 11 weeks
• however, sulindac treatment reduces the number and size of tumors

cellular
increased keratinocyte proliferation ( J:201145 )
• with increased survival in doxycycline-treated mice

hematopoietic system
increased granulocyte number ( J:201145 )
• in the skin of doxycycline-treated mice
increased CD4-positive, alpha-beta T cell number ( J:201145 )
• in the skin of doxycycline-treated mice
• however, doxycycline withdrawal restores CD4+ T cell numbers




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory