Phenotypes associated with this allele

• Allele Symbol: Camk2d^tm1.1Mean
• Allele Name: targeted mutation 1.1, Mark Anderson
• Allele ID: MGI:5555902
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Camk2d^tm1.1Mean/Camk2d^tm1.1Mean	involves: 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:5555943

Genotype
MGI:5555943

hm1

• Allelic Composition: Camk2d^tm1.1Mean/Camk2d^tm1.1Mean
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:207291 )

• STZ-treated mice subjected to myocardial infarction exhibit resistance to increased mortality compared with similarly treated wild-type mice

• however, survival is normal in mice not treated with STZ

cardiovascular system

abnormal sinoatrial node conduction ( J:207291 )

• STZ-treated mice subjected to myocardial infarction (MI) exhibit improved intrinsic sinus node function compared with similarly treated wild-type mice

abnormal response to cardiac infarction ( J:207291 )

• streptozotocin (STZ)-treated mice subjected to myocardial infarction (MI) exhibit resistance to increased mortality with increased resting heart rate, reduced episodes of very low heart rate, improved activity-related heart rate increases, improved intrinsic sinus node function, reduced apoptosis in the sinoatrial node and reduced fibrosis compared with similarly treated wild-type mice

• however, survival is normal in mice not treated with STZ and STZ mice subjected to MI exhibit normal left ventricle contractile function and volume

homeostasis/metabolism

abnormal response to cardiac infarction ( J:207291 )

• streptozotocin (STZ)-treated mice subjected to myocardial infarction (MI) exhibit resistance to increased mortality with increased resting heart rate, reduced episodes of very low heart rate, improved activity-related heart rate increases, improved intrinsic sinus node function, reduced apoptosis in the sinoatrial node and reduced fibrosis compared with similarly treated wild-type mice

• however, survival is normal in mice not treated with STZ and STZ mice subjected to MI exhibit normal left ventricle contractile function and volume

cellular

decreased apoptosis ( J:207291 )

• in the sinoatrial node of STZ-treated mice subjected to myocardial infarction

oxidative stress ( J:207291 )

• increased reactive oxygen species in right atrial tissue after streptozotocin (STZ) treatment