Phenotypes associated with this allele

• Allele Symbol: Tg(Igh-Mir210)#aKgcs
• Allele Name: transgene insertion #a, Kenneth G C Smith
• Allele ID: MGI:5555968
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Igh-Mir210)#aKgcs/Tg(Igh-Mir210)#aKgcs	B6.Cg-Tg(Igh-Mir210)#aKgcs	MGI:5555977

Genotype
MGI:5555977

tg1

• Allelic Composition: Tg(Igh-Mir210)#aKgcs/Tg(Igh-Mir210)#aKgcs
• Genetic Background: B6.Cg-Tg(Igh-Mir210)#aKgcs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:205868 )

N • the IgM response to NP-KLH remains intact and response to NP-Ficoll is normal

abnormal class switch recombination ( J:205868 )

• reduced class-switched IgG1 antibody response to NP-KLH

decreased pro-B cell number ( J:205868 )

• in the bone marrow

decreased mature B cell number ( J:205868 )

• in the bone marrow

increased B-1a cell number ( J:205868 )

• 20-fold in the spleen

• 2.5 factor increase in the peritoneal cavity

decreased pre-B cell number ( J:205868 )

• in the bone marrow

abnormal spleen marginal zone morphology ( J:205868 )

• mice lack a well-defined marginal zone

decreased marginal zone B cell number ( J:205868 )

decreased IgA level ( J:205868 )

• greater than 10-fold

decreased IgG1 level ( J:205868 )

• greater than 10-fold

decreased IgG2a level ( J:205868 )

• greater than 10-fold

decreased IgG2b level ( J:205868 )

• greater than 10-fold

decreased IgG3 level ( J:205868 )

• greater than 10-fold

hematopoietic system

abnormal class switch recombination ( J:205868 )

• reduced class-switched IgG1 antibody response to NP-KLH

decreased pro-B cell number ( J:205868 )

• in the bone marrow

decreased mature B cell number ( J:205868 )

• in the bone marrow

increased B-1a cell number ( J:205868 )

• 20-fold in the spleen

• 2.5 factor increase in the peritoneal cavity

decreased pre-B cell number ( J:205868 )

• in the bone marrow

abnormal spleen marginal zone morphology ( J:205868 )

• mice lack a well-defined marginal zone

decreased marginal zone B cell number ( J:205868 )

decreased IgA level ( J:205868 )

• greater than 10-fold

decreased IgG1 level ( J:205868 )

• greater than 10-fold

decreased IgG2a level ( J:205868 )

• greater than 10-fold

decreased IgG2b level ( J:205868 )

• greater than 10-fold

decreased IgG3 level ( J:205868 )

• greater than 10-fold