Phenotypes associated with this allele

• Allele Symbol: Pld1^tm1.1Gdp
• Allele Name: targeted mutation 1.1, Gilbert Di Paolo
• Allele ID: MGI:5556064
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pld1^tm1.1Gdp/Pld1^tm1.1Gdp	involves: 129/SvJ * C57BL/6	MGI:5556071

Genotype
MGI:5556071

hm1

• Allelic Composition: Pld1^tm1.1Gdp/Pld1^tm1.1Gdp
• Genetic Background: involves: 129/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced hepatic autophagy in starved Pld1^tm1.1Gdp/Pld1^tm1.1Gdp mice

cellular

abnormal autophagy ( J:207283 )

• food restriction fails to expand LC3+ compartments with smaller autophagosomes in the liver unlike in wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:207283 )

N • fed and starved mice exhibit normal serum glucose and insulin levels

abnormal autophagy ( J:207283 )

• food restriction fails to expand LC3+ compartments with smaller autophagosomes in the liver unlike in wild-type mice