All Phenotypes Tdrd12<tm1Yam> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tdrd12^tm1Yam
targeted mutation 1, Shinya Yamanaka
MGI:5556124

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tdrd12^tm1Yam/Tdrd12^tm1Yam	involves: 129S4/SvJae * C57BL/6	MGI:5556125

Allelic Composition	Tdrd12^tm1Yam/Tdrd12^tm1Yam
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tdrd12^tm1Yam mutation (1 available); any Tdrd12 mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:202012 )

abnormal spermatid morphology ( J:202012 )

• absence of round spermatids

• narrow with large vacuolated spaces and devoid of late-stage germ cells

small seminiferous tubules ( J:202012 )

• narrow

testicular atrophy ( J:202012 )

arrest of spermatogenesis ( J:202012 )

• fail to proceed beyond the prepachytene stage

• absence of the XY body in late zygotene to pachytene spermatocytes

male infertility ( J:202012 )

abnormal sperm physiology ( J:202012 )

• derepression of retrotransposons in germ cells

endocrine/exocrine glands