All Phenotypes Mastl<tm1.1Mama> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mastl^tm1.1Mama
targeted mutation 1.1, Marcos Malumbres
MGI:5556126

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mastl^tm1.1Mama/Mastl^tm1.1Mama	Not Specified	MGI:5556129
cn2	Mastl^tm1.1Mama/Mastl^tm1.1Mama Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺	Not Specified	MGI:5556128

Allelic Composition	Mastl^tm1.1Mama/Mastl^tm1.1Mama
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mastl^tm1.1Mama mutation (0 available); any Mastl mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitosis ( J:201971 )

• mitotic aberrations in prometaphase, including defective chromosome condensation and abnormal spindles in primary MEFs following acute expression of cre

• about 75% of MEFs display mitotic arrest following acute expression of cre

• duration of mitosis is increased in primary MEFs following acute expression of cre

• however, no differences in the kinetics of mitotic entry are detected and the function of the spindle assembly checkpoint appears normal in primary MEFs following acute expression of cre

abnormal mitotic spindle morphology ( J:201971 )

decreased fibroblast proliferation ( J:201971 )

• in primary MEFs following acute expression of cre

Allelic Composition	Mastl^tm1.1Mama/Mastl^tm1.1Mama Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mastl^tm1.1Mama mutation (0 available); any Mastl mutation (36 available)
Polr2a^{tm1(cre/ERT2)Bbd} mutation (3 available); any Polr2a mutation (92 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitosis ( J:201971 )

• following treatment with tamoxifen at E12.5, at E14.5 an increase in mitotic figures is seen in the neuroepithelium

• mitotic figures display an accumulation of prometaphases/metaphases

embryo

abnormal embryonic neuroepithelium morphology ( J:201971 )

• following treatment with tamoxifen at E12.5, at E14.5 an increase in mitotic figures is seen in the neuroepithelium

nervous system

abnormal embryonic neuroepithelium morphology ( J:201971 )

• following treatment with tamoxifen at E12.5, at E14.5 an increase in mitotic figures is seen in the neuroepithelium

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24