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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rock1tm1.2Itl
targeted mutation 1.2, inGenious Targeting Laboratory
MGI:5556290
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rock1tm1.2Itl/Rock1tm1.2Itl Not Specified MGI:5556296


Genotype
MGI:5556296
hm1
Allelic
Composition		 Rock1tm1.2Itl/Rock1tm1.2Itl
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1tm1.2Itl mutation (0 available); any Rock1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Absence of autophagosomes in Rock1tm1.2Itl/Rock1tm1.2Itl starved hearts

cellular
abnormal autophagy ( J:207251 )
• starved heart tissue fails to exhibit an increase in autophagosomes and exhibits a decrease in LC3 puncta formation compared with wild-type tissue

homeostasis/metabolism
abnormal autophagy ( J:207251 )
• starved heart tissue fails to exhibit an increase in autophagosomes and exhibits a decrease in LC3 puncta formation compared with wild-type tissue




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory