Phenotypes associated with this allele

• Allele Symbol: Usp1^{tm1d(KOMP)Wtsi}
• Allele Name: targeted mutation 1d, Wellcome Trust Sanger Institute
• Allele ID: MGI:5556385
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp1^tm1d(KOMP)Wtsi/Usp1^tm1d(KOMP)Wtsi	involves: C57BL/6N	MGI:5557974

Genotype
MGI:5557974

hm1

• Allelic Composition: Usp1^{tm1d(KOMP)Wtsi}/Usp1^{tm1d(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0039_1_E12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:207363 )

N • mice exhibit normal osteoclast abundance and activity

decreased bone mineral density ( J:207363 )

• at E18.5 and P12

decreased bone volume ( J:207363 )

• at E18.5

abnormal osteoid morphology ( J:207363 )

• reduced deposition of osteoid on emergent bone spicules

delayed bone ossification ( J:207363 )

• defects in ossification of the cranial and long bones

increased bone resorption ( J:207363 )

homeostasis/metabolism

decreased circulating alkaline phosphatase level ( J:207363 )

• reduced serum bone alkaline phosphatase levels at E18.5