Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(tetO-Sox9)Msan}
• Allele Name: targeted mutation 1, Maike Sander
• Allele ID: MGI:5557984
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(tetO-Sox9)Msan/Gt(ROSA)26Sor^tm1(rtTA,EGFP)Nagy Shh^tm1(EGFP/cre)Cjt/Shh^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5557985
cx2	Gt(ROSA)26Sor^tm1(tetO-Sox9)Msan/Gt(ROSA)26Sor^+ Tg(SFTPC-rtTA)5Jaw/0	Not Specified	MGI:5557986

Genotype
MGI:5557985

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(tetO-Sox9)Msan}/Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}; Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

abnormal lung morphology ( J:202984 )

• decrease in airway spaces at E18.5

lung cyst ( J:202984 )

• develop large, cyst-like structures at the distal epithelial branch tips

• cystic buds appear to collapse by E18.5

small lung ( J:202984 )

• noticeable by E14.5 and more significant by E16.5

growth/size/body

lung cyst ( J:202984 )

• develop large, cyst-like structures at the distal epithelial branch tips

• cystic buds appear to collapse by E18.5

Genotype
MGI:5557986

cx2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(tetO-Sox9)Msan}/Gt(ROSA)26Sor⁺; Tg(SFTPC-rtTA)5Jaw/0
• Genetic Background: Not Specified

mortality/aging

perinatal lethality, complete penetrance ( J:202984 )

• when dox treatment was started at E15.5, all 3 double mutants died at birth

respiratory system

abnormal pulmonary alveolus epithelium morphology ( J:202984 )

• in dox treated mice, distal epithelium remains columnar failing to undergo the columnar to squamous transition

cellular

abnormal cell differentiation ( J:202984 )

• when dox treatment is started at E9.5 or E15.5, terminal differentiation of airway cells is inhibited and all differentiated cells are Sox9-negative