Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ifngr1tm1.1Rds targeted mutation 1.1, Robert D Schreiber MGI:5558045 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mice infected with L. monocytogenes
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• mice infected with L. monocytogenes exhibit increased mortality and spleen and liver bacterial counts compared with control mice
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• in mice infected with L. monocytogenes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mice infected with L. monocytogenes
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• from NK and NK T cells of mice infected with L. monocytogenes
• however, production in CD8+ T cells is normal
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• reduced from CD8a+ dendritic cells of mice infected with L. monocytogenes
• production from Ly6c+ monocytes is temporarily delayed
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• mice infected with L. monocytogenes exhibit increased mortality, spleen and liver bacterial counts, reduced IL12b production from CD8a+ dendritic cells compared with control mice
• intravenous L. monocytogenes infection results in reduced bacterial burden
• however, treatment with IL4 neutralizing antibody reduces bacterial burden
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• in mice infected with L. monocytogenes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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