All Phenotypes Gfi1b<tm1.1Haho> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gfi1b^tm1.1Haho/Gfi1b^tm1.1Haho Tg(Mx1-cre)1Cgn/0	involves: 129S4/SvJaeSor * C57BL/6	MGI:5558065
cn2	Col1a1^{tm1(tetO-cre)Haho}/? Gfi1b^tm1.1Haho/Gfi1b^tm1.1Haho	involves: 129S4/SvJaeSor * C57BL/6	MGI:5558066

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal megakaryocyte differentiation ( J:207446 )

• no mature megakaryocytes are detected in bone marrow

hematopoietic system

anemia ( J:207446 )

abnormal bone marrow cell morphology/development ( J:207446 )

• lethally irradiated animals transplanted with mutant bone marrow and treated with doxycycline show erythroid progenitor arrest and megakaryocyte differentiation defects in a wild-type bone marrow environment, but do not exhibit anemia or cytopenia; defects are blood cell-autonomous

abnormal megakaryocyte differentiation ( J:207446 )

• no mature megakaryocytes are detected in bone marrow

absent erythroid progenitor cell ( J:207446 )

• after induction, no erythroid precursors at or beyond the proerythroblast (monopotent progenitors) stage are detected in the bone marrow

abnormal megakaryocyte progenitor cell morphology ( J:207446 )

• numbers of bipotent megakaryocyte and erythrocyte progenitor cells (pre-MegEs) are increased in bone marrow

decreased hemoglobin content ( J:207446 )

• moribund animals have hemoglobin levels of 1-2 g/dl

thrombocytopenia ( J:207446 )

• moribund animals have severe thrombocytopenia; some animals have no detectable platelets

absent platelets ( J:207446 )

• in some animals

mortality/aging

postnatal lethality, complete penetrance ( J:207446 )

• pI:pC activation of cre-mediated excision in animals 4-8 weeks of age is lethal in less than 3 weeks

Allelic Composition	Col1a1^{tm1(tetO-cre)Haho}/? Gfi1b^tm1.1Haho/Gfi1b^tm1.1Haho
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1^{tm1(tetO-cre)Haho} mutation (1 available); any Col1a1 mutation (163 available)
Gfi1b^tm1.1Haho mutation (0 available); any Gfi1b mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:207446 )

• doxycycline activation of cre-mediated excision in animals 4-8 weeks of age is lethal in less than 3 weeks

hematopoietic system

abnormal megakaryocyte differentiation ( J:207446 )

• no mature megakaryocytes are detected in bone marrow

anemia ( J:207446 )

absent erythroid progenitor cell ( J:207446 )

• after induction, no erythroid precursors at or beyond the proerythroblast (monopotent progenitors) stage are detected in the bone marrow

abnormal megakaryocyte progenitor cell morphology ( J:207446 )

• numbers of bipotent megakaryocyte and erythrocyte progenitor cells (pre-MegEs) are increased in bone marrow

decreased hemoglobin content ( J:207446 )

• moribund animals have hemoglobin levels of 1-2 g/dl

thrombocytopenia ( J:207446 )

• moribund animals have severe thrombocytopenia; some animals have no detectable platelets

absent platelets ( J:207446 )

• in some animals

cellular

abnormal megakaryocyte differentiation ( J:207446 )

• no mature megakaryocytes are detected in bone marrow

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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