Phenotypes associated with this allele

• Allele Symbol: Slc30a8^tm1.1Htwt
• Allele Name: targeted mutation 1.1, Hirotaka Watada
• Allele ID: MGI:5558084
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Slc30a8^tm1.1Htwt/Slc30a8^tm1.1Htwt Tg(Ins2-cre)25Mgn/0	involves: C57BL/6 * CBA/JNCrlj * DBA	MGI:5558089

Genotype
MGI:5558089

cn1

• Allelic Composition: Slc30a8^tm1.1Htwt/Slc30a8^tm1.1Htwt; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: C57BL/6 * CBA/JNCrlj * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

liver/biliary system phenotype ( J:204003 )

N • mice exhibit normal liver function

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:204003 )

N • mice exhibit normal insulin tolerance, glucagon secretion and metabolic response to a high-fat diet

increased insulin secretion ( J:204003 )

• in mice fed chow or a high-fat diet

• twice as much as in control cells with a large portion of secreted insulin degraded through a single liver passage

impaired glucose tolerance ( J:204003 )

• mildly in mice fed chow

abnormal insulin clearance ( J:204003 )

• increased insulin clearance after glucose challenge

• proinsulin to insulin ratio is slightly higher than in wild-type mice

abnormal zinc homeostasis ( J:204003 )

• low zinc content in beta cell islets

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:204003 )

• insulin crystallization failure at 6 and 20 weeks with atypical insulin granules lacking a detectable dense core

• however, mice exhibit normal beta cell area and vessel structure and counts in islets

increased insulin secretion ( J:204003 )

• in mice fed chow or a high-fat diet

• twice as much as in control cells with a large portion of secreted insulin degraded through a single liver passage