Phenotypes associated with this allele

• Allele Symbol: Kiss1r^tm1.1Aeh
• Allele Name: targeted mutation 1.1, Allan E Herbison
• Allele ID: MGI:5558092
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kiss1r^tm1.1Aeh/Kiss1r^tm1.1Aeh Tg(Gnrh1-cre)1Dlc/0	involves: C57BL/6 * CBA	MGI:5558863
cn2	Kiss1r^tm1.1Aeh/Kiss1r^tm1.1Aeh Tg(Gnrh1-cre)1Dlc/0 Tg(Gnrh1-Kiss1r)#Aeh/0	involves: C57BL/6 * CBA	MGI:5558864

Genotype
MGI:5558863

cn1

• Allelic Composition: Kiss1r^tm1.1Aeh/Kiss1r^tm1.1Aeh; Tg(Gnrh1-cre)1Dlc/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced gonadal size in Kiss1r^tm1.1Aeh/Kiss1r^tm1.1Aeh Tg(Gnrh1-cre)1Dlc mice is rescued by the Tg(Gnrh1-Kiss1r)#Aeh transgene

reproductive system

azoospermia ( J:206044 )

♂

decreased ovary weight ( J:206044 )

♀

decreased testis weight ( J:206044 )

♂

vagina atresia ( J:206044 )

♀

female infertility ( J:206044 )

♀

male infertility ( J:206044 )

♂

homeostasis/metabolism

decreased circulating follicle stimulating hormone level ( J:206044 )

• in female and male mice

decreased luteinizing hormone level ( J:206044 )

♂ • in male mice with a failure to respond to kisspeptin treatment

endocrine/exocrine glands

decreased ovary weight ( J:206044 )

♀

decreased testis weight ( J:206044 )

♂

cellular

azoospermia ( J:206044 )

♂

Genotype
MGI:5558864

cn2

• Allelic Composition: Kiss1r^tm1.1Aeh/Kiss1r^tm1.1Aeh; Tg(Gnrh1-cre)1Dlc/0; Tg(Gnrh1-Kiss1r)#Aeh/0
• Genetic Background: involves: C57BL/6 * CBA

Reduced gonadal size in Kiss1r^tm1.1Aeh/Kiss1r^tm1.1Aeh Tg(Gnrh1-cre)1Dlc mice is rescued by the Tg(Gnrh1-Kiss1r)#Aeh transgene

reproductive system

reproductive system phenotype ( J:206044 )

N • female and male mice exhibit normal testes weight and mature sexually

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:206044 )

N • mice exhibit normal follicle-stimulating hormone levels