Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fkbpltm1.1(KOMP)Wtsi targeted mutation 1.1, Wellcome Trust Sanger Institute MGI:5558157 |
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| Summary |
4 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - TCP
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IMPC - TCP
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• heterozygous intercrosses fail to yield any homozygotes, with embryonic lethality occurring before E8.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following intradermal implantation of Lewis lung carcinoma (LLC) tumors, heterozygotes show an increase in CD31-stained blood vessels with the endothelium appearing thicker and less organized than in similarly-treated wild-type controls, indicating enhanced tumor angiogenesis
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• in an ex vivo aortic ring assay, heterozygous mutant aortae show an enhanced pattern of sprouting with a significant increase in average vessel length relative to wild-type aortae
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• in an ex vivo aortic ring assay, heterozygous mutant aortae show enhanced sprouting of vessels relative to wild-type aortae
• in an in vivo sponge assay, bFGF-treated polyether sponges implanted in mutant mice show a significantly higher number (15% to 20%) of endomucin-stained vessels relative to wild-type controls
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• following intradermal implantation of Lewis lung carcinoma (LLC) tumors, heterozygotes show an increase in CD31-stained blood vessels with the endothelium appearing thicker and less organized than in similarly-treated wild-type controls, indicating enhanced tumor angiogenesis
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• following intradermal implantation of LLC tumors, LLC cells grown on the rear dorsum of heterozygous mutant mice show an increased growth rate relative to those in similarly-treated wild-type controls
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• following intradermal implantation of LLC tumors, heterozygotes show a significantly shorter survival (defined as time to reach >600 mm3 in tumor volume) than similarly-treated wild-type controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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