Phenotypes associated with this allele

• Allele Symbol: Tg(PVR)1Kkst
• Allele Name: transgene insertion 1, Satoshi Koike
• Allele ID: MGI:5558897
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Ticam1^tm1Tsse/Ticam1^tm1Tsse Tg(PVR)1Kkst/0	involves: 129 * C57BL/6 * ICR	MGI:5558901
cx2	Mavs^tm1Tsse/Mavs^tm1Tsse Tg(PVR)1Kkst/0	involves: 129 * C57BL/6 * ICR	MGI:5558902
tg3	Tg(PVR)1Kkst/0	involves: ICR	MGI:5558900

Genotype
MGI:5558901

cx1

• Allelic Composition: Ticam1^tm1Tsse/Ticam1^tm1Tsse; Tg(PVR)1Kkst/0
• Genetic Background: involves: 129 * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:179625 )

• in polivirus-infected mice at low doses

• however, high doses provides the same lethality as in Tg(PVR)1Kkst mice

immune system

abnormal interferon-alpha secretion ( J:179625 )

• following injection of high poliovirus titers, mice fail to exhibit an increase in serum IFN-alpha Tg(PVR)1Kkst mice

increased susceptibility to Picornaviridae infection ( J:179625 )

• mice infected with low doses of poliovirus exhibit increased organ titers, reduced lethality and fail to exhibit an increase in IFN-alpha serum levels compared with Tg(PVR)1Kkst mice

• mouse embryonic fibroblasts are more susceptible to poliovirus-induced cell death compared with cells from Tg(PVR)1Kkst mice

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:179625 )

• in polivirus-infected mice at low doses

• however, high doses provides the same lethality as in Tg(PVR)1Kkst mice

Genotype
MGI:5558902

cx2

• Allelic Composition: Mavs^tm1Tsse/Mavs^tm1Tsse; Tg(PVR)1Kkst/0
• Genetic Background: involves: 129 * C57BL/6 * ICR

mortality/aging

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:179625 )

• when poliovirus loads is not very high, polivirus-infected mice exhibit lightly less lethality compared with Tg(PVR)1Kkst mice

• however, poliovirus-infected mice exhibit normal lethality at higher levels

immune system

abnormal interferon-alpha secretion ( J:179625 )

• following injection of high poliovirus titers, mice exhibit less of an increase in serum IFN Tg(PVR)1Kkst mice

decreased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:179625 )

• when poliovirus loads is not very high, polivirus-infected mice exhibit lightly less lethality compared with Tg(PVR)1Kkst mice

• however, poliovirus-infected mice exhibit normal lethality at higher levels

Genotype
MGI:5558900

tg3

• Allelic Composition: Tg(PVR)1Kkst/0
• Genetic Background: involves: ICR

immune system

increased susceptibility to Picornaviridae infection ( J:153943 )

• increased neurovirulence in response to infection with poliovirus strains Mohney, Lansing and Leon