Phenotypes associated with this allele

• Allele Symbol: Rax^{tm1.1(cre/ERT2)Sbls}
• Allele Name: targeted mutation 1.1, Seth Blackshaw
• Allele ID: MGI:5558909
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rax^tm1.1(cre/ERT2)Sbls/Rax^+ Yap1^tm1Hmc/Yap1^tm1Hmc	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:6716882

Genotype
MGI:6716882

cn1

• Allelic Composition: Rax^{tm1.1(cre/ERT2)Sbls}/Rax⁺; Yap1^tm1Hmc/Yap1^tm1Hmc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:304126 )

• S-opsin and M-cone opsins are reduced in the retina, with S-opsin signal drastically decreased dorsally while M-opsin almost absent ventrally

• however, the number of cones is not changed

retina gliosis ( J:304126 )

• 4-OHT-treated mice show reactive gliosis in the retina at 12 months of age

nervous system

abnormal glial cell physiology ( J:304126 )

• marker analysis of mice treated with 4-hydroxy-tamoxifen (4-OHT) at P10 shows Muller cell homeostasis dysfunction at 12 months of age