Phenotypes associated with this allele

• Allele Symbol: Megf8^tm1.1Ddg
• Allele Name: targeted mutation 1.1, David D Ginty
• Allele ID: MGI:5558914
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Megf8^tm1.1Ddg/Megf8^tm1.1Ddg	involves: 129S6/SvEvTac * BALB/cJ	MGI:5558937

Genotype
MGI:5558937

hm1

• Allelic Composition: Megf8^tm1.1Ddg/Megf8^tm1.1Ddg
• Genetic Background: involves: 129S6/SvEvTac * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:206541 )

• mice die by E16.5

cardiovascular system

cardiovascular system phenotype ( J:206541 )

N • at early stages, mice exhibit normal endocardial cushion mesenchymal cells

abnormal cardiac outflow tract development ( J:206541 )

• transposition

abnormal direction of heart looping ( J:206541 )

• left-right inversion of heart looping in 7 of 21 mice

abnormal mitral valve morphology ( J:206541 )

• complete or nearly complete absence of the mitral valve

abnormal tricuspid valve morphology ( J:206541 )

• complete or nearly complete absence of the tricuspid valve

abnormal heart atrium morphology ( J:206541 )

• swollen atria

atrial septal defect ( J:206541 )

ventricular septal defect ( J:206541 )

heart right ventricle outflow tract stenosis ( J:206541 )

• pulmonary stenosis

nervous system

abnormal axon extension ( J:206541 )

• cultured trigeminal ganglia explants are less sensitive to the inhibitory effects of BMP4 on axon outgrowth compared with wild-type explants

abnormal axon fasciculation ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face

• at E11.5, the vagus and glossopharyngeal nerves are slightly defasciculated with wayward branching away from the main fiber bundle compared with wild-type mice

exencephaly ( J:206541 )

• in 16 of 45 mice

abnormal glossopharyngeal nerve morphology ( J:206541 )

abnormal trigeminal nerve morphology ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face

• however, the mandibular branch is normal

abnormal maxillary nerve morphology ( J:206541 )

• slight undergrowth of the maxillary branch

abnormal ophthalmic nerve morphology ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face

abnormal vagus nerve morphology ( J:206541 )

abnormal spinal nerve morphology ( J:206541 )

• shorter than normal at E11.5

• at E13.5, the radial and ulnar nerves do not fully extend into the limbs with less branching compared to in wild-type mice

limbs/digits/tail

abnormal autopod morphology ( J:206541 )

• duplication of bones in the hand

preaxial polydactyly ( J:206541 )

• pre-axial in both the forelimbs and hindlimbs with 6 to 7 digits per limb

delayed limb development ( J:206541 )

• immature limbs at E13.5

skeleton

abnormal thoracic cage morphology ( J:206541 )

• wider and shorter than in wild-type mice

split sternum ( J:206541 )

delayed bone ossification ( J:206541 )

• in the rib cage

embryo

abnormal direction of embryo turning ( J:206541 )

• left-right inversion of embryonic turning in 5 of 15 mice

homeostasis/metabolism

edema ( J:206541 )

• severe peripheral edema

cellular

abnormal axon extension ( J:206541 )

• cultured trigeminal ganglia explants are less sensitive to the inhibitory effects of BMP4 on axon outgrowth compared with wild-type explants

abnormal axon fasciculation ( J:206541 )

• defasciculation of the ophthalmic branch of the trigeminal ganglion axons within the face

• at E11.5, the vagus and glossopharyngeal nerves are slightly defasciculated with wayward branching away from the main fiber bundle compared with wild-type mice