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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Megf8tm1.2Ddg
targeted mutation 1.2, David D Ginty
MGI:5558931
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Megf8tm1.2Ddg/Megf8tm1.2Ddg
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S6/SvEvTac * C57BL/6J * CBA/J MGI:5558940
cn2
 		Megf8tm1.2Ddg/Megf8tm1.2Ddg
Mesp1tm2(cre)Ysa/Mesp1+ 		involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj MGI:5558939


Genotype
MGI:5558940
cn1
Allelic
Composition		 Megf8tm1.2Ddg/Megf8tm1.2Ddg
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Megf8tm1.2Ddg mutation (1 available); any Megf8 mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:206541 )
N
• radial and ulnar nerve development is normal
abnormal axon fasciculation ( J:206541 )
• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice
abnormal ophthalmic nerve morphology ( J:206541 )
• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice

limbs/digits/tail
limbs/digits/tail phenotype ( J:206541 )
N
• mice exhibit normal limb maturity

cellular
abnormal axon fasciculation ( J:206541 )
• defasciculation of the ophthalmic branch of the trigeminal nerve but more variable than in null mice




Genotype
MGI:5558939
cn2
Allelic
Composition		 Megf8tm1.2Ddg/Megf8tm1.2Ddg
Mesp1tm2(cre)Ysa/Mesp1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Megf8tm1.2Ddg mutation (1 available); any Megf8 mutation (97 available)
Mesp1tm2(cre)Ysa mutation (3 available); any Mesp1 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:206541 )
N
• mice exhibit a normal heart phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory