Phenotypes associated with this allele

• Allele Symbol: Tgfb1^{tm1(Tgfb3)Kul}
• Allele Name: targeted mutation 1, Ashok B Kulkarni
• Allele ID: MGI:5559039
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgfb1^tm1(Tgfb3)Kul/Tgfb1^tm1(Tgfb3)Kul	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5559055

Genotype
MGI:5559055

hm1

• Allelic Composition: Tgfb1^{tm1(Tgfb3)Kul}/Tgfb1^{tm1(Tgfb3)Kul}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced size, kyphosis, tooth abnormalities, and decreased mineral density and dental attrition in Tgfb1^{tm1(Tgfb3)Kul}/Tgfb1^{tm1(Tgfb3)Kul} mice

mortality/aging

mortality/aging ( J:204892 )

N • unlike Tgfb1^tm1N homozygotes, no embryonic lethality is observed

premature death ( J:204892 )

• median life span is 30 weeks

reproductive system

infertility ( J:204892 )

craniofacial

craniofacial phenotype ( J:204892 )

N • palate development is normal

abnormal tooth morphology ( J:204892 )

• tooth defects are not as severe as in Tgfb1^tm1N homozygotes

abnormal incisor morphology ( J:204892 )

• white, undermineralized and chipped

abnormal incisor color ( J:204892 )

• white

misaligned incisors ( J:204892 )

• upper and lower incisors are offset and strike one another rather than self-sharpening

abnormal tooth mineralization ( J:204892 )

• incisors are undermineralized with lower incisors displaying a significant reduction in relative mineral opacity

abnormal enamel morphology ( J:204892 )

ameloblast degeneration ( J:204892 )

abnormal tooth attrition ( J:204892 )

• molars show signs of attrition with wearing of the molar cuspids

malocclusion ( J:204892 )

• severe in 3 of 34 mice

skeleton

abnormal tooth morphology ( J:204892 )

• tooth defects are not as severe as in Tgfb1^tm1N homozygotes

abnormal incisor morphology ( J:204892 )

• white, undermineralized and chipped

abnormal incisor color ( J:204892 )

• white

misaligned incisors ( J:204892 )

• upper and lower incisors are offset and strike one another rather than self-sharpening

abnormal tooth mineralization ( J:204892 )

• incisors are undermineralized with lower incisors displaying a significant reduction in relative mineral opacity

abnormal enamel morphology ( J:204892 )

ameloblast degeneration ( J:204892 )

abnormal tooth attrition ( J:204892 )

• molars show signs of attrition with wearing of the molar cuspids

malocclusion ( J:204892 )

• severe in 3 of 34 mice

kyphosis ( J:204892 )

decreased osteoblast cell number ( J:204892 )

• on the trabecular bone

abnormal bone ossification ( J:204892 )

• defect in secondary ossification

immune system

immune system phenotype ( J:204892 )

N • unlike Tgfb1^tm1N homozygotes, mice do not develop multifocal inflammation

increased monocyte cell number ( J:204892 )

abnormal T cell morphology ( J:204892 )

• slight alteration in the ratio of CD4+ and CD8+ cells

increased regulatory T cell number ( J:204892 )

• increased percent in the peripheral lymph nodes

growth/size/body

abnormal tooth morphology ( J:204892 )

• tooth defects are not as severe as in Tgfb1^tm1N homozygotes

abnormal incisor morphology ( J:204892 )

• white, undermineralized and chipped

abnormal incisor color ( J:204892 )

• white

misaligned incisors ( J:204892 )

• upper and lower incisors are offset and strike one another rather than self-sharpening

abnormal tooth mineralization ( J:204892 )

• incisors are undermineralized with lower incisors displaying a significant reduction in relative mineral opacity

abnormal enamel morphology ( J:204892 )

ameloblast degeneration ( J:204892 )

abnormal tooth attrition ( J:204892 )

• molars show signs of attrition with wearing of the molar cuspids

malocclusion ( J:204892 )

• severe in 3 of 34 mice

decreased body weight ( J:204892 )

• decreased body weight that is more apparent with age

• even following supplementation with a high fat dough diet

decreased body height ( J:204892 )

• small stature

adipose tissue

decreased subcutaneous adipose tissue amount ( J:204892 )

decreased total body fat amount ( J:204892 )

decreased white fat cell size ( J:204892 )

homeostasis/metabolism

decreased circulating insulin level ( J:204892 )

• in fasting mice

decreased circulating leptin level ( J:204892 )

improved glucose tolerance ( J:204892 )

behavior/neurological

increased food intake ( J:204892 )

• relative to weight

integument

decreased subcutaneous adipose tissue amount ( J:204892 )

hematopoietic system

increased monocyte cell number ( J:204892 )

abnormal T cell morphology ( J:204892 )

• slight alteration in the ratio of CD4+ and CD8+ cells

increased regulatory T cell number ( J:204892 )

• increased percent in the peripheral lymph nodes