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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm1(tetO-EGFP/Rac1*)Shaw
targeted mutation 1, Andrey S Shaw
MGI:5559077
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
Tg(Nphs1-rtTA*3G)8Jhm/0 		involves: 129S4/SvJae * C57BL/6 MGI:5559184
cx2
 		Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
Tg(NPHS2-rtTA2*M2)1Jbk/0 		involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:5559183
ot3
 		Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y involves: 129S4/SvJae * C57BL/6 MGI:5559182


Genotype
MGI:5559184
cx1
Allelic
Composition		 Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
Tg(Nphs1-rtTA*3G)8Jhm/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(tetO-EGFP/Rac1*)Shaw mutation (0 available); any Hprt1 mutation (1279 available)
Tg(Nphs1-rtTA*3G)8Jhm mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:206088 )
N
• glomeruli are unremarkable
increased urine protein level ( J:206088 )
• doxycycline-treated mice exhibit proteinuria that peaks at 4 days and decreases gradually over time unlike control mice

homeostasis/metabolism
increased urine protein level ( J:206088 )
• doxycycline-treated mice exhibit proteinuria that peaks at 4 days and decreases gradually over time unlike control mice




Genotype
MGI:5559183
cx2
Allelic
Composition		 Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
Tg(NPHS2-rtTA2*M2)1Jbk/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(tetO-EGFP/Rac1*)Shaw mutation (0 available); any Hprt1 mutation (1279 available)
Tg(NPHS2-rtTA2*M2)1Jbk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased urine protein level ( J:206088 )
• however, proteinuria abates 1 week post-induction
• after 2 days of doxycycline treatment
podocyte foot process effacement ( J:206088 )
• segmental in doxycycline-treated mice

homeostasis/metabolism
increased urine protein level ( J:206088 )
• after 2 days of doxycycline treatment
• however, proteinuria abates 1 week post-induction




Genotype
MGI:5559182
ot3
Allelic
Composition		 Hprt1tm1(tetO-EGFP/Rac1*)Shaw/Y
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(tetO-EGFP/Rac1*)Shaw mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:206088 )
N
• mice do not develop proteinuria




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory