All Phenotypes Foxi3<tm1.2Akg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxi3^tm1.2Akg/Foxi3^tm1.2Akg	involves: 129X1/SvJ	MGI:6114104
hm2	Foxi3^tm1.2Akg/Foxi3^tm1.2Akg	involves: 129X1/SvJ * BALB/c	MGI:5559213
ht3	Foxi3^em3Akg/Foxi3^tm1.2Akg	involves: 129X1/SvJ * C57BL/6	MGI:7493640
cx4	Foxi2^tm1.1Akg/Foxi2^tm1.1Akg Foxi3^tm1.2Akg/Foxi3^tm1.2Akg	involves: 129X1/SvJ * BALB/cJ	MGI:6114103

Allelic Composition	Foxi3^tm1.2Akg/Foxi3^tm1.2Akg
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxi3^tm1.2Akg mutation (0 available); any Foxi3 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system development ( J:228880 )

• absence of the geniculate and petrosal placodes at E9.5

abnormal vestibulocochlear ganglion morphology ( J:228880 )

• absent or severely deformed

abnormal geniculate ganglion morphology ( J:228880 )

• absent or severely deformed

abnormal trigeminal ganglion morphology ( J:228880 )

• absence of the mandibular branch of the trigeminal ganglion

• however, the ophthalmic and maxillary branches remain

hearing/vestibular/ear

abnormal otic placode morphology ( J:228880 )

• expression analysis and absence of any signs of a placode-like thickening or invagination of ectoderm adjacent to the hindbrain indicate that the otic placode is not induced

• however, olfactory and lens placodes are formed as in controls

cellular

increased embryonic tissue cell apoptosis ( J:228880 )

• apoptotic cells are seen in the pre-placode region at the 4-8 somite stage

craniofacial

abnormal otic placode morphology ( J:228880 )

• expression analysis and absence of any signs of a placode-like thickening or invagination of ectoderm adjacent to the hindbrain indicate that the otic placode is not induced

• however, olfactory and lens placodes are formed as in controls

embryo

increased embryonic tissue cell apoptosis ( J:228880 )

• apoptotic cells are seen in the pre-placode region at the 4-8 somite stage

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:207523 )

• some pups are born, but die immediately after birth, death is believed to be the result of an inability to breathe

embryonic lethality during organogenesis, incomplete penetrance ( J:207523 )

• embryos begin dying after E9.5

craniofacial

abnormal Meckel's cartilage morphology ( J:207523 )

• Meckel's cartilage is misshapen and missing some elements in E16.5 embryos

abnormal temporal bone squamous part morphology ( J:207523 )

• squamosal portion of temporal bone is malformed in E18.5 embryos

abnormal mandible morphology ( J:207523 )

• only a small portion of the mandible develops in E18.5 embryos

• mandible is fused to maxilla; this portion is small, truncated and asymmetrical

abnormal maxilla morphology ( J:207523 )

• maxilla is malformed and fused to mandible in E18.5 embryos

syngnathia ( J:207523 )

• only a small anterior portion of the mandible develops and is fused to the distal end of maxilla

abnormal palatine bone morphology ( J:207523 )

• palatines reduced in size in E18.5 embryos

absent zygomatic bone ( J:207523 )

• jugal is absent in E18.5 embryos

cranioschisis ( J:207523 )

• 50% of E18.5 embryos exhbit a wide gap between the frontal bones of skull

absent incus ( J:207523 )

• in E18.5 embryos

absent malleus ( J:207523 )

• in E18.5 embryos

absent stapes ( J:207523 )

• in E18.5 embryos

absent pharyngeal arches ( J:207523 )

• coronal sections through the pharyngeal region of 15ss (somite stage) embryos fail to develop into distinct arches

• no contact points are observed between pharyngeal endoderm and ectoderm

• arch mesenchymes are continuous

• 25ss (somite stage) embryos exhibit smooth endoderm rather than defined arches

abnormal facial morphology ( J:207523 )

• neonatal pups have small faces, and lack a mouth, external ear pinnae and whiskers

small face ( J:207523 )

absent mouth ( J:207523 )

• the lower half of the neonatal face is covered in continuous ectoderm

absent outer ear ( J:207523 )

• external ear pinnae are missing

embryo

increased cranial neural crest cell apoptosis ( J:207523 )

• increased apoptosis in neural crest cells found in the posterior region of the presumptive first branchial arch at 25ss

absent pharyngeal arches ( J:207523 )

• coronal sections through the pharyngeal region of 15ss (somite stage) embryos fail to develop into distinct arches

• no contact points are observed between pharyngeal endoderm and ectoderm

• arch mesenchymes are continuous

• 25ss (somite stage) embryos exhibit smooth endoderm rather than defined arches

abnormal pharyngeal pouch morphology ( J:207523 )

• pharyngeal pouches are not present

hearing/vestibular/ear

absent outer ear ( J:207523 )

• external ear pinnae are missing

absent inner ear ( J:207523 )

• inner ear is absent in E18.5 embryos

abnormal middle ear morphology ( J:207523 )

absent incus ( J:207523 )

• in E18.5 embryos

absent malleus ( J:207523 )

• in E18.5 embryos

absent stapes ( J:207523 )

• in E18.5 embryos

absent tympanic ring ( J:207523 )

• in E18.5 embryos

integument

absent vibrissae ( J:207523 )

cellular

increased cranial neural crest cell apoptosis ( J:207523 )

• increased apoptosis in neural crest cells found in the posterior region of the presumptive first branchial arch at 25ss

skeleton

abnormal Meckel's cartilage morphology ( J:207523 )

• Meckel's cartilage is misshapen and missing some elements in E16.5 embryos

abnormal temporal bone squamous part morphology ( J:207523 )

• squamosal portion of temporal bone is malformed in E18.5 embryos

abnormal mandible morphology ( J:207523 )

• only a small portion of the mandible develops in E18.5 embryos

• mandible is fused to maxilla; this portion is small, truncated and asymmetrical

abnormal maxilla morphology ( J:207523 )

• maxilla is malformed and fused to mandible in E18.5 embryos

syngnathia ( J:207523 )

• only a small anterior portion of the mandible develops and is fused to the distal end of maxilla

abnormal palatine bone morphology ( J:207523 )

• palatines reduced in size in E18.5 embryos

absent zygomatic bone ( J:207523 )

• jugal is absent in E18.5 embryos

cranioschisis ( J:207523 )

• 50% of E18.5 embryos exhbit a wide gap between the frontal bones of skull

absent incus ( J:207523 )

• in E18.5 embryos

absent malleus ( J:207523 )

• in E18.5 embryos

absent stapes ( J:207523 )

• in E18.5 embryos

growth/size/body

abnormal facial morphology ( J:207523 )

• neonatal pups have small faces, and lack a mouth, external ear pinnae and whiskers

small face ( J:207523 )

absent mouth ( J:207523 )

• the lower half of the neonatal face is covered in continuous ectoderm

absent outer ear ( J:207523 )

• external ear pinnae are missing

Allelic Composition	Foxi3^em3Akg/Foxi3^tm1.2Akg
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxi3^em3Akg mutation (0 available); any Foxi3 mutation (22 available)
Foxi3^tm1.2Akg mutation (0 available); any Foxi3 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:336768 )

• mice die between birth and day 5

respiratory system

abnormal respiration ( J:336768 )

• mice exhibit respiratory abnormalities

growth/size/body

decreased body weight ( J:336768 )

• mice are underweight and fail to thrive after birth

endocrine/exocrine glands

athymia ( J:336768 )

hematopoietic system

athymia ( J:336768 )

immune system

athymia ( J:336768 )

craniofacial

craniofacial phenotype ( J:336768 )

N	• mice do not show defects in the mandible or the maxilla

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:336768 )

N	• mice do not show defects in the external, middle, or inner ears

Allelic Composition	Foxi2^tm1.1Akg/Foxi2^tm1.1Akg Foxi3^tm1.2Akg/Foxi3^tm1.2Akg
Genetic Background	involves: 129X1/SvJ * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxi2^tm1.1Akg mutation (0 available); any Foxi2 mutation (20 available)
Foxi3^tm1.2Akg mutation (0 available); any Foxi3 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system development ( J:228880 )

• no significant difference from mice homozygous null for Foxi3 alone

abnormal vestibulocochlear ganglion morphology ( J:228880 )

• absent or severely deformed

abnormal geniculate ganglion morphology ( J:228880 )

• absent or severely deformed

abnormal trigeminal ganglion morphology ( J:228880 )

• absence of the mandibular branch of the trigeminal ganglion

• however, the ophthalmic and maxillary branches remain

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