Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh}
• Allele Name: targeted mutation 1.1, City of Hope, Beckman Research Institute
• Allele ID: MGI:5559204
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gt(ROSA)26Sor^tm1.1(Mir26a-1)Coh/Gt(ROSA)26Sor^+ Tg(Ins2-cre)25Mgn/0	involves: C57BL/6 * DBA	MGI:6402899
ot2	Gt(ROSA)26Sor^tm1.1(Mir26a-1)Coh/?	involves: 129 * C57BL/6	MGI:5559205

Genotype
MGI:6402899

cx1

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh}/Gt(ROSA)26Sor⁺; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:286108 )

• when mice are fed a high-fat diet compared with controls

small pancreatic islets ( J:286108 )

• when mice are fed a high-fat diet compared with controls

decreased insulin secretion ( J:286108 )

• 3-fold from isolated islets treated with glucose

• however, response to arginine or KCl is normal and first-phase secretion is normal

homeostasis/metabolism

decreased insulin secretion ( J:286108 )

• 3-fold from isolated islets treated with glucose

• however, response to arginine or KCl is normal and first-phase secretion is normal

decreased susceptibility to diet-induced obesity ( J:286108 )

• when mice are fed a high-fat diet despite comparable food intake

decreased fasting circulating glucose level ( J:286108 )

• mice fed a high-fat diet exhibit reduced fasting glucose levels compared with control mice fed the same diet

decreased circulating insulin level ( J:286108 )

• mice fed a high-fat diet exhibit reduced insulin levels compared with control mice fed the same diet

improved glucose tolerance ( J:286108 )

• when mice are fed a high-fat diet compared with controls

increased insulin sensitivity ( J:286108 )

• when mice are fed a high-fat diet compared with controls

growth/size/body

decreased susceptibility to diet-induced obesity ( J:286108 )

• when mice are fed a high-fat diet despite comparable food intake

Genotype
MGI:5559205

ot2

• Allelic Composition: Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh}/?
• Genetic Background: involves: 129 * C57BL/6

Increase in the number of islets in Gt(ROSA)26Sor^{tm1.1(Mir26a-1)Coh}/? pancreas

endocrine/exocrine glands

increased pancreatic islet number ( J:201964 )

• at P10

abnormal endocrine pancreas development ( J:201964 )

• pancreatic endocrine cell differentiation is enhanced in vitro

• enhanced proliferation and differentiation of pancreatic endocrine cells