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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Meiobtm1.1Ics
targeted mutation 1.1, Mouse Clinical Institute
MGI:5559212
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Meiobtm1.1Ics/Meiobtm1.1Ics involves: C57BL/6NTac MGI:5559215


Genotype
MGI:5559215
hm1
Allelic
Composition		 Meiobtm1.1Ics/Meiobtm1.1Ics
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meiobtm1.1Ics mutation (0 available); any Meiob mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Reduced size of testes and ovaries in Meiobtm1.1Ics/Meiobtm1.1Ics mice

reproductive system
decreased oocyte number ( J:203426 )
• starting at P3
absent oocytes ( J:203426 )
• at P10
abnormal meiosis ( J:203426 )
• spermatocytes and oocytes exhibit impaired homologous synapsis, double-strand break repair and meiotic homologous recombination unlike wild-type cells
increased male germ cell apoptosis ( J:203426 )
• increased apoptosis from P10 in testes
increased ovary apoptosis ( J:203426 )
• increased apoptosis from E18.5 in ovaries
small testis ( J:203426 )
• 3.8 times
arrest of spermatogenesis ( J:203426 )
• at P10, no stage beyond primary spermatocyte is observed unlike in wild-type mice

cellular
decreased oocyte number ( J:203426 )
• starting at P3
absent oocytes ( J:203426 )
• at P10
abnormal meiosis ( J:203426 )
• spermatocytes and oocytes exhibit impaired homologous synapsis, double-strand break repair and meiotic homologous recombination unlike wild-type cells
increased male germ cell apoptosis ( J:203426 )
• increased apoptosis from P10 in testes
increased ovary apoptosis ( J:203426 )
• increased apoptosis from E18.5 in ovaries
abnormal double-strand DNA break repair ( J:203426 )
• impaired double-strand break repair during meiosis in spermatocytes and oocytes

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:203426 )
• impaired double-strand break repair during meiosis in spermatocytes and oocytes

endocrine/exocrine glands
increased ovary apoptosis ( J:203426 )
• increased apoptosis from E18.5 in ovaries
small testis ( J:203426 )
• 3.8 times




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory