Phenotypes associated with this allele

• Allele Symbol: Slx4^tm1.2Jrou
• Allele Name: targeted mutation 1.2, John Rouse
• Allele ID: MGI:5559219
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slx4^tm1.2Jrou/Slx4^tm1.2Jrou	B6.129P2-Slx4^tm1.2Jrou	MGI:5559492
hm2	Slx4^tm1.2Jrou/Slx4^tm1.2Jrou	involves: 129P2/OlaHsd * C57BL/6	MGI:5559490
cx3	Fan1^tm1.1Jrou/Fan1^tm1.1Jrou Slx4^tm1.2Jrou/Slx4^tm1.2Jrou	involves: 129P2/OlaHsd	MGI:5897800

Genotype
MGI:5559492

hm1

• Allelic Composition: Slx4^tm1.2Jrou/Slx4^tm1.2Jrou
• Genetic Background: B6.129P2-Slx4^tm1.2Jrou

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:204996 )

• fewer than expected mice are obtained at weaning

embryonic lethality, incomplete penetrance ( J:204996 )

• fewer than expected mice are obtained at E13.5

reproductive system

small testis ( J:204996 )

• at 10 weeks

cellular

increased sensitivity to induced cell death ( J:204996 )

• in mouse embryonic fibroblasts treated with DNA interstrand crosslinking agents (nitrogen mustard and MMC)

abnormal DNA repair ( J:204996 )

induced chromosome breakage ( J:204996 )

• chromatid breaks and radial structures in MMC-treated mouse embryonic fibroblasts

endocrine/exocrine glands

small testis ( J:204996 )

• at 10 weeks

homeostasis/metabolism

abnormal DNA repair ( J:204996 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Fanconi anemia complementation group P	DOID:0111092	OMIM:613951	J:204996
Fanconi-like syndrome		DOID:0090066	OMIM:227850	J:204996

Genotype
MGI:5559490

hm2

• Allelic Composition: Slx4^tm1.2Jrou/Slx4^tm1.2Jrou
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

preweaning lethality, complete penetrance ( J:204996 )

• no mice are obtained from crossing heterozygotes

Genotype
MGI:5897800

cx3

• Allelic Composition: Fan1^tm1.1Jrou/Fan1^tm1.1Jrou; Slx4^tm1.2Jrou/Slx4^tm1.2Jrou
• Genetic Background: involves: 129P2/OlaHsd

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:232403 )

• increase in sensitivity to mitomycin C compared to either single homozygote