Phenotypes associated with this allele

• Allele Symbol: Ptger2^tm1.1Kand
• Allele Name: targeted mutation 1.1, Katrin I Andreasson
• Allele ID: MGI:5559328
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ptger2^tm1.1Kand/Ptger2^tm1.1Kand Tg(ITGAM-cre)2781Gkl/0	involves: C57BL/6 * CBA	MGI:5559329

Genotype
MGI:5559329

cn1

• Allelic Composition: Ptger2^tm1.1Kand/Ptger2^tm1.1Kand; Tg(ITGAM-cre)2781Gkl/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal microglial cell physiology ( J:202677 )

• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia

decreased susceptibility to endotoxin shock ( J:202677 )

• expression analysis indicates a blunted systemic and brain innate immune response to systemic LPS treatment

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:202677 )

• decrease in the inflammatory response and microglial and astrocyte activation after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in the substantia nigra pars compacta

• however, no rescue of the loss of TH+ neurons in MPTP treated mice is detected

increased physiological sensitivity to xenobiotic ( J:202677 )

• increase in dopamine turnover in MPTP treated mutants compared to similarly treated controls

nervous system

abnormal microglial cell physiology ( J:202677 )

• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia

hematopoietic system

abnormal microglial cell physiology ( J:202677 )

• expression analysis suggests a decrease in the inflammatory and proliferative state of microglia