Phenotypes associated with this allele

• Allele Symbol: Esr1^{tm1.1(cre)And}
• Allele Name: targeted mutation 1.1, David J Anderson
• Allele ID: MGI:5559339
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Esr1^tm1.1(cre)And/Esr1^+	B6.129S6(Cg)-Esr1^tm1.1(cre)And	MGI:5559349

Genotype
MGI:5559349

ht1

• Allelic Composition: Esr1^{tm1.1(cre)And}/Esr1⁺
• Genetic Background: B6.129S6(Cg)-Esr1^{tm1.1(cre)And}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased aggression towards mice ( J:207677 )

• photostimulation does not elicit aggression in males injected with an AAV (adenoassociated virus) in which cre activity results in deletion of the channelrhodopsin2 sequence; AAV-injected control males show attack behavior upon photostimulation

• mice injected with an AAV encoding NpHR3.0 (inhibitor of Esr1-expressing neuron activity) and photostimulated at the moment of approach can show either prevention of initiation of attack or interruption of an ongoing attack (sometimes even retreat) while mice injected with an AAV encoding mCherry only do not show interruption of attack upon photostimulation

increased aggression towards mice ( J:207677 )

• photostimulation of Esr1 expressing neurons in the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl) in males injected with a cre-activated adenoassociated virus (AAV) with a floxed channelrhodopsin 2/mCherry (ChR2/mCherry) cassette in reverse orientation results in intense attack towards female and castrated male intruders (cre expression results in inversion of the ChR2 cassette followed by expression in Esr1 positive neurons)

abnormal social investigation ( J:207677 )

• males injected with an adenoassociated virus (AAV) encoding channelrhodopsin2 show increased numbers and duration of close investigation episodes with weak ChR2 expression or low intensity photostimulation; such conditions also promote mounting behavior towards castrated males or female mice with longer latency than for attack behavior

• mice injected with an AAV encoding NpHR3.0 (inhibitor of Esr1-expressing neuron activity) and photostimulated showed interruption of ongoing close investigation