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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Thy1-APPSweAut)A7Tiwa
transgene insertion A7, Takeshi Iwatsubo
MGI:5559448
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(Thy1-APPSweAut)A7Tiwa/0 Not Specified MGI:5559449


Genotype
MGI:5559449
tg1
Allelic
Composition		 Tg(Thy1-APPSweAut)A7Tiwa/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:204270 )
• develop progressive amyloid deposition in cerebral cortices at around 9-12 months of age
• young (4 month) mutants treated with the anti-amyloid beta antibody 266 exhibit increased levels of monomer amyloid beta species in an antibody-bound form, without affecting that of total amyloid beta

homeostasis/metabolism
amyloid beta deposits ( J:204270 )
• develop progressive amyloid deposition in cerebral cortices at around 9-12 months of age
• young (4 month) mutants treated with the anti-amyloid beta antibody 266 exhibit increased levels of monomer amyloid beta species in an antibody-bound form, without affecting that of total amyloid beta

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:204270




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory