All Phenotypes Scrib<tm1.1Cj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scrib^tm1.1Cj
targeted mutation 1.1, Neal Copeland and Nancy Jenkins
MGI:5559569

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Scrib^tm1.1Cj/Scrib^tm1.1Cj Tg(Pax6-cre,GFP)1Pgr/0	involves: 129S1/Sv * FVB/N	MGI:5559585

Allelic Composition	Scrib^tm1.1Cj/Scrib^tm1.1Cj Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^tm1.1Cj mutation (0 available); any Scrib mutation (54 available)
Tg(Pax6-cre,GFP)1Pgr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

iris hyperplasia ( J:204591 )

• hyperplastic, occludes the pupil

abnormal cornea epithelium morphology ( J:204591 )

• irregularly arranged and squamous cells instead of stratified cuboidal cells

abnormal lens morphology ( J:204591 )

• misshapen, small and vacuolated with central opacity

abnormal lens epithelium morphology ( J:204591 )

• squamous rather than cuboidal cells with loss of E-cadherin early in development

• cells acquire mesenchymal traits

cataract ( J:204591 )

• central opacity

small lens ( J:204591 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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