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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rapgef3tm1.1Chen
targeted mutation 1.1, Ju Chen
MGI:5559594
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rapgef3tm1.1Chen/Rapgef3tm1.1Chen B6.129(Cg)-Rapgef3tm1.1Chen MGI:5559602


Genotype
MGI:5559602
hm1
Allelic
Composition
Rapgef3tm1.1Chen/Rapgef3tm1.1Chen
Genetic
Background
B6.129(Cg)-Rapgef3tm1.1Chen
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef3tm1.1Chen mutation (1 available); any Rapgef3 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in fasted mice fed standard chow (at 3 and 16 weeks) or a high fat diet (at 28 weeks)
• faster glucose clearance from serum after glucose administration
• in fasted mice fed a high fat diet
• slightly in fasted mice fed a high fat diet
• however, insulin level response to blood glucose elevation is normal
• in mice fed a high fat diet
• however, mice fed standard chow exhibit normal glucose tolerance
• in mice fed a high fat diet

adipose tissue
• in mice fed a high fat diet
• mouse embryonic fibroblasts exhibit reduced differentiation into adipocytes compared with wild-type cells
• in mice fed standard chow
• in mice fed a high fat diet

growth/size/body
• in mice fed standard chow or a high fat diet
• in mice injected with leptin
• in mice fed standard chow or a high fat diet

behavior/neurological
• in mice fed standard chow
• in mice injected with leptin during the first dark cycle
• however, food intake of a high fat diet is normal





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory