Analysis Tools
behavior/neurological
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• 12 month old mice show a reduction in spontaneous ambulatory activity and are less active
• 12 month old mice treated with methyl L-DOPA show rescue of hypoactivity
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bradykinesia
(
J:204793
)
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• 12 and 16 month old mice show an increase in the time required to perform the pole test, indicating impaired motor performance and bradykinesia
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nervous system
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• progressive degeneration of substantia nigra pars compacta dopaminergic neurons starting around 12 months of age
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• mice show accumulation of hyperphosphorylated microtubule-associated protein tau in the brain at 12 months of age
• however, Lewy bodies or Lewy neurites are not seen in the substantia nigra
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• striatal uptake of a tracer of presynaptic dopamine transporter is decreased in 12 month old mice and density of TH-immunoreactive staining is decreased in striatal sections indicating degeneration of nigrostriatal dopaminergic terminals
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• progressive degeneration of substantia nigra pars compacta dopaminergic neurons starting around 12 months of age
• however, neuronal death is not seen in the cerebral cortex, hippocampus or striatum at 12 or 16 months of age
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Parkinson's disease 8 | DOID:0060371 |
OMIM:607060 |
J:204793 | |
