Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-PRKCE*A159E)388Robo
• Allele Name: transgene insertion 388, Roberto Bolli
• Allele ID: MGI:5559989
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-PRKCE*A159E)388Robo/?	involves: FVB	MGI:5559990

Genotype
MGI:5559990

tg1

• Allelic Composition: Tg(Myh6-PRKCE*A159E)388Robo/?
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:133484 )

• absolute heart weight and ratio of heart to body weight are increased by 28% and 21%, respectively

cardiac hypertrophy ( J:133484 )

• absolute heart weight and ratio of heart to body weight are increased by 28% and 21%, respectively

• however, no evidence of fibrosis and no difference in systolic blood pressure

• wall thickness at end-diastole of the anterior (AWTh), and posterior (PWTh), and left ventricular mass are increased, indicating concentric hypertrophy

abnormal myocardial fiber physiology ( J:133484 )

• percentage of cardiomyocyte shortening is slightly decreased

• baseline calcium level is slightly lower and amplitude of the calcium transient is decreased in isolated cardiomyocytes

• times from start to 80% decay of the calcium signal and 50% decay of the calcium signal are prolonged in cardiomyocytes indicating that myofilament sensitivity to calcium is increased in hearts

growth/size/body

increased heart weight ( J:133484 )

• absolute heart weight and ratio of heart to body weight are increased by 28% and 21%, respectively

cardiac hypertrophy ( J:133484 )

• absolute heart weight and ratio of heart to body weight are increased by 28% and 21%, respectively

• however, no evidence of fibrosis and no difference in systolic blood pressure

• wall thickness at end-diastole of the anterior (AWTh), and posterior (PWTh), and left ventricular mass are increased, indicating concentric hypertrophy