Analysis Tools
digestive/alimentary system
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• in some mice cell numbers are depleted in some regions of both the small intestine and colon
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• severe decrease in the number of Paneth cells
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• hyperplastic and expanded crypt regions in both adult and weanling jejunum crypts
• increase in apoptosis coincident with the increase in proliferation
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• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age
• adenomas and adenocarcinomas are seen in the small intestine only except for in the founder mouse that had tumors in the small intestine and colon at 15.5 months of age
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• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age
• lesions are typically polyp-shaped or flat
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neoplasm
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• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age
• adenomas and adenocarcinomas are seen in the small intestine only except for in the founder mouse that had tumors in the small intestine and colon at 15.5 months of age
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• the majority of mice develop adenomas or adenocarcinomas at 12-17 months of age
• lesions are typically polyp-shaped or flat
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endocrine/exocrine glands
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• severe decrease in the number of Paneth cells
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• hyperplastic and expanded crypt regions in both adult and weanling jejunum crypts
• increase in apoptosis coincident with the increase in proliferation
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cellular
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• in some mice cell numbers are depleted in some regions of both the small intestine and colon
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